妇科病患者宫颈分泌物支原体培养及药敏结果

Mycoplasma culture and drug sensitivity of cervical secretions in patients with gynecological diseases

目的分析妇科病患者宫颈分泌物的支原体培养以及药敏结果,为临床合理用药提供参考。方法选取2016年2月至2017年1月期间于深圳市龙华区中心医院妇科门诊就医的226例妇科患者作为研究对象,对其宫颈分泌物支原体培养的阳性率进行分析,并针对阳性样本进行药敏试验。结果宫颈分泌物样本的支原体阳性率为56.64%(128/226),其中单纯感染解脲支原体(Uu)的患者有92例,占71.87%,单纯感染人型支原体(Mh)的患者共6例,占4.69%,Uu和Mh混合感染的患者共30例,占23.44%。感染Uu的患者显著高于感染Mh的患者(P<0.05)。支原体阳性标本的药敏实验发现,敏感性较高的抗菌药物包括交沙霉素(JOS)、阿奇霉素(AZL)、左氧氟沙星(L-OFL)、克拉霉素(CLA)、罗红霉素(ROX)以及氧氟沙星(OFL)等。结论宫颈分泌物支原体对于喹诺酮类以及大环内酯类药物具有较高敏感性,对支原体阳性标本进行药敏实验有利于为临床合理使用抗生素提供依据。

Objective To summarize and analyze the Mycoplasma culture and drug sensitivity results of cervical secretions in patients with gynecological diseases,and provide reference for clinical rational use of drugs. Methods 226 cases of patients with gynecological disease and who seek medical advice in Department of Gynecological clinic of Central Hospital of Longhua District from February,2016 to January,2017 were selected as the research objects,and the positive rate of mycoplasma culture of cervical secretions were analyzed,and the drug sensitivity tests were carried out for the positive samples. Results The positive rate of Mycoplasma in cervical secretion samples was 56.64%（128/226）;in which,there were 92 cases of Ureaplasma urealyticum（Uu）infection,accounting for 71.87%,6 cases of Mycoplasma hominis（Mh）,accounting for 4.69%,and 30 cases of mixed infection of Uu and Mh,accounting for 23.44%. The percentage of patients infected with Uu were significantly higher than those infected with Mh（P〈0.05）. The mycoplasma isolates were highly sensitive to antimicrobial agents including josamycin（JOS）,azithromycin（AZL）and levofloxacin（L-OFL）,clarithromycin（CLA）,roxithromycin（ROX）and levofloxacin（OFL）. Conclusion The mycoplasma isolated from cervical secretion were highly sensitive to quinolones and macrolides drugs;drug susceptibility test for Mycoplasma positive specimens should be helpful for rational use of antibiotics.