子宫上皮细胞稳定性细胞游离亚铁原卟啉对宫颈癌的诊断意义

The diagnostic significance of the uterine epithelial cells stability of the cells free ferrous protoporphyrin for cervical cancer

目的探讨子宫上皮细胞稳定性细胞游离亚铁原卟啉(FH)对宫颈癌的诊断价值。方法选取2014年2月~2016年12月湖南省脑科医院接受宫颈癌筛查的女性患者303例,经病理学诊断宫颈癌患者56例,宫颈上皮内瘤变Ⅱ~Ⅲ(CINⅡ~Ⅲ)患者112例,宫颈刮片检查健康正常健康者135例,均行子宫上皮细胞稳定性FH检测和液基薄层细胞检测(TCT)。将病理学诊断结果作为金标准,分析上皮细胞稳定性FH和TCT对宫颈癌与CINⅡ~Ⅲ检测的灵敏度、特异度、准确度、约登指数、阳性和阴性预测值。结果经上皮细胞稳定性FH检测,宫颈癌患者与CINⅡ~Ⅲ患者的总阳性率均明显高于正常健康者(P<0.05),且宫颈癌患者明显高于CINⅡ~Ⅲ患者(P<0.05);上皮细胞稳定性FH检测宫颈癌患者54例,CINⅡ~Ⅲ患者97例,TCT检测宫颈癌患者49例,CINⅡ~Ⅲ患者93例;上皮细胞稳定性FH检测的灵敏度、特异度、准确度、约登指数、阳性预测值及阴性预测值均高于TCT检测。结论上皮细胞稳定性FH在宫颈癌高表达,检测结果有较高的准确度、灵敏度、特异度、阳性预测值和阴性预测值。

Objective To investigate the diagnostic value of the uterine epithelial cells stability of the cells free ferrous protoporphyrin（FH） for cervical cancer. Methods Three hundred and three female patients with cervical cancer screening in Brain Hospital of Hunan Province were selected from February 2014 to December 2016, and there were 56 cases of cervical cancer and 112 cases of cervical intraepithelial neoplasia Ⅱ-Ⅲ（CIN Ⅱ-Ⅲ） by pathological diagnosis and135 cases of normal healthy women by cervical scraping smear test, who were detected by uterine epithelial cells stability FH test and thinprep cytologic test（TCT）. The pathological diagnosis was used as the gold standard, and the sensitivities, specificity, accuraciy, Youden indexes, positive and negative predictive values of the uterine epithelial cells stability FH and TCT for cervical cancer and CINⅡ-Ⅲ were analyzed. Results The total FH positive rate of cervical cancer patients and CIN Ⅱ-Ⅲ patients were significantly higher than that of normal healthy subjects（P〈0.05）, of which the patients with cervical cancer were significantly higher than of the CINⅡ-Ⅲ patients（P〈0.05）. There were54 cases patients of cervical cancer and 97 patients of CIN Ⅱ-Ⅲ who were detected by uterine epithelial cells stability FH, and there were 49 patients of cervical cancer and 93 patients of CIN Ⅱ-Ⅲ who were detected by TCT. The sensitivities, specificity, accuracies, Youden indexes, positive predictive value and negative predictive value of the uterine epithelial cells stability FH test were higher than those of the TCT. Conclusion The expressions of the uterine epithelial cells stability FH test ar e increased in cervical cancer, which has higher accuracies, sensitivity, specificity,positive and negative predictive values for the detection of cervical cancer.