摘要
目的:探索自制健康人心理性衰老量表反映个体心理性衰老程度的分布规律及其与外周血白细胞端粒长度的关系,为科学评价衰老提供参考。方法:根据所设置的9个年龄组分层随机抽样,运用课题组自制量表收集调查对象的心理性衰老现况资料;分析个体心理性衰老得分情况及其与年龄、端粒长度的相关性。结果:现场实证研究共发放问卷2 100份,有效回收2 060份,回收有效率为98.10%,男女比为0.95:1。心理性衰老总分为8.62~23.14,认知功能、情绪、人格、动机与需要4个维度衰老分值分别为2.25~10.77,1.45~6.73,0.96~4.22,1.50~7.18;年龄与心理性衰老总分相关性较高(r=0.721,P<0.001)。被测对象端粒相对长度为1.06±0.26,不同年龄组的端粒相对长度的差异有统计学意义(F=35.803,P<0.001);端粒长度与年龄(r=–0.964,P<0.001)和心理性衰老总分(r=–0.915,P=0.004)均呈负相关。结论:健康人心理性衰老量表的现场实证研究表明心理性衰老得分随年龄增长呈升高趋势,并与端粒长度呈负相关,可为衰老综合评价提供参考。
Objective: To explore the distribution of psychological aging in healthy population and its relationship with telomere length in peripheral blood leukocyte, and to provide reference for aging evaluation. Methods: Stratified random samples were obtained according to age and they were divided into 9 age groups. The age-related psychological information were collected from healthy people by using the self-made scale. Situation of psychological aging, correlation between age and telomere length and score of this scale were analyzed by statistical software. Results: A total of 2 100 questionnaires were distributed, and 2 060 of them were valid and has been recovered, with an efficiency of 98.10%. The ratio of male to female was 0.95:1; psychological aging score was in the range of 8.62-23.14; cognitive function score was in the range of 2.25-10.77; emotion score was in the range of 1.45-6.73; personality score was in the range of 0.96-4.22; motivation score was in the range of 1.50-7.18. The correlation coefficient of psychological aging scores with age was 0.721 (/9〈0.001). The average relative telomere length was 1.06+0.26, and relative telomere length in different age groups were significantly different (F=35.803, P〈0.001). Telomere length was negatively correlated with age (r=-0.964, P〈0.001) and psychological aging scores (r=-0.915, P=0.004). Conclusion: The empirical study of physiological aging scale in healthy population shows that the scores of physical aging are increased with age and that the telomere length is negatively correlated with aging scores, suggesting that the scale can provide reference for the comprehensive evaluation of aging.
作者
贺子强
姚慧
龙耀
周建明
冯江
黄河浪
HE Ziqiang;YAO Hui;LONG Yao;ZHOU Jianming;FENG Jiang;HUANG Helang(Department of Epidemiology;Jiangxi Province Key Laboratory of Preventive Medicine;Grade 2014, School of Public Health, Nanchang University, Nanchang 330006, China)
出处
《中南大学学报(医学版)》
CAS
CSCD
北大核心
2018年第1期76-81,共6页
Journal of Central South University :Medical Science
关键词
心理性衰老
端粒长度
实证研究
physiological aging
telomere length
empirical study