2型糖尿病内脏脂肪面积与肾小球滤过率相关分析

Association of Visceral Adiposity with Glomerular Filtration Rate in Type 2 Diabetes Mellitus

目的探讨2型糖尿病患者内脏脂肪面积与肾小球滤过率的关系。方法应用Inbody720人体成分分析仪对120例2型糖尿病患者进行内脏脂肪面积、体脂肪、体脂百分比、骨骼肌等指标测量,同时测量空腹血糖、尿素氮、肌酐、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇,计算肾小球滤过率(GFR),测量身高、体重、腰围、臀围,计算体重指数(BMI)和腰臀比(WHR),对人体成分参数和肾功能、血脂等指标进行分析。结果线性相关分析显示GFR与内脏脂肪面积(r=0.233)、体脂肪(r=0.236)、BMI(r=0.366)、WHR(r=0.377)存在相关,差异有统计学意义(P<0.05);多元线性回归分析显示内脏脂肪面积(β=0.095,P=0.007)是GFR的独立影响因素。结论 2型糖尿病合并内脏型肥胖者肾小球滤过率水平下降,内脏脂肪面积与2型糖尿病患者肾小球滤过率密切相关,是独立影响因素。

Objective To explore the association of visceral adiposity with glomerular filtration rate in type 2 diabetes. Methods We collected the body composition data with human body composition analyzer （inbody 720）,and collected anthropometric data and blood lipids,fasting blood glucose,creatinine. And their relative intensities were analyzed. Results Linear correlation analysis showed that GFR was positively correlated with visceral adiposity（r=0.233）,body fat（r=0.236）,BMI（r=0.366） and WHR（r=0.377）,and multiple linear regression analysis showed that visceral adiposity was an independent risk factor for GFR（β=0.095,P=0.007）. Conclusion Visceral adiposity is closely related to glomerular filtration rate in patients with type 2 diabetes mellitus,and is an independent risk factor.