摘要
根据磷霉素的作用机理设计合成了其类似物15个,并测定了最低抑菌浓度(MIC)。初步结果表明左旋磷霉素衍生物抗菌作用较强,有5个化合物对某些菌抗菌作用超过左旋磷霉素钙。
Fifteen fosfomycin analogues were synthesized and their MICagainst several bacteria strains were determined.Preliminary results showed thatcompounds 7,8,9,13 and 15 possessed higher activity than calcium(-)-fosfo-mycin(11)against some bacteria.The derivatives 10,and 14 of(+)-fosfomycinwere less active than(-)-fosfomycin derivatives(8 and 13).
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第9期391-394,共4页
Chinese Journal of Pharmaceuticals
关键词
磷霉素
合成
抗菌活性
fosfomycin analogues
synthesis
resolution
MIC
