木棉花水提取物抗炎镇痛作用的实验研究

Experimental study on the anti-inflammatory and analgesic effects of the water extract of Bombax Malabaricum DC. Flower

目的初步研究木棉花水提取物抗炎镇痛作用。方法采用二甲苯和醋酸作为致炎和致痛因子,通过小鼠耳廓肿胀实验、腹腔毛细血管通透性实验与扭体实验,考察灌胃高、中、低剂量的木棉花水提取物的抗炎、镇痛作用。结果小鼠对于木棉花水提取物的最大耐受量为300 g/kg;木棉花水提取物高剂量(150 g/kg)和中剂量(100 g/kg)均能抑制小鼠耳廓肿胀,降低小鼠腹腔血管通透性;木棉花水提取液各剂量组均能有效地减少小鼠的扭体次数,且作用随剂量增加而增强。结论木棉花水提取物具有抗炎镇痛作用。

Objective To study the anti-inflammatory and analgesic effect of water extract of Bombax malabaricum DC. Flower. Methods The xylene and acetic acid were used as inflammation and pain factors. The auricle swelling test, intraperitoneal capillary permeability test and writhing experiment were performed to study the anti-inflammatory and analgesic effect with high, medium and low dose of water extract of Bombax malabaricum DC. Flower. Results The maximum tolera- ted dose of mice for Bombax malabaricnm DC. Flower was 300 g/kg. High dose （ 150 g/kg） and medium dose （ 100 g/kg） of water extract of Bombax malabaricum DC. Flower could both inhibit mouse auricle swelling and reduce mouse peritoneal vascular permeability. All dosages of the water extract of Bombax malabaricum DC. Flower were effective in reducing the number of writhing in mice, and the effect is strengthened with the increase of dosage. Conclusion Water extract of Bom- bax malabaricum DC. Flower has anti-inflammatory and analgesic effects.