摘要
瘦素(leptin)是由控制各种生理过程的脂肪组织合成和分泌的一类激素,通过作用于靶细胞膜上的瘦素受体并经信号传导在各器官和系统中发挥一系列生物学效应。肾脏是高血压常见的靶器官之一。相关研究表明,瘦素在高血压肾损害中发挥作用,其机制可能与氧化应激及其炎症反应有关。本文以瘦素对高血压肾损害及其相关机制作一综述,并探讨瘦素对高血压肾损害发病机制研究进展。
Leptin which is a kind of synthesis and secretion of hormone that participates in various physiological processes is the role of the leptin receptor on the target cell membrane and the signal transduction through a series of biological effects in different organs and systems. Kidney is one of the common target organs of hypertension, and related research shows that leptin plays a role in hypertensive kidney damage, whose mechanism may be related to oxidative stress and its inflamma- tory reaction. The paper reviewed leptin on renal damage in hypertension and its related mechanisms, to explore the leptin on renal pathogenesis of hypertension research progress.
出处
《广州医药》
2018年第1期110-113,共4页
Guangzhou Medical Journal
基金
国家自然科学基金资助项目(81760861)
广西科学研究与技术开发计划项目(桂科能1598025-29)
桂林市科学研究与技术开发计划项目(20130120-1)
关键词
瘦素
瘦素抵抗
高血压
肾损害
氧化应激
Leptin
Leptin resistance
Hypertension
Renal damage
Oxidative stress
