多发性骨髓瘤患者血清lncRNA HOTAIR表达量与血清β_2微球蛋白及预后的相关性

The correlation between serum lncRNA HOTAIR expression level,serum beta2-microglobulin and prognosis in patients with multiple myeloma

目的分析多发性骨髓瘤(MM)患者血清长链非编码RNA(lncRNA)HOTAIR表达量与血清β_2微球蛋白(β_2-MG)及预后的相关性。方法选取100例MM患者作为病例组,根据化疗治疗效果将其分为有效组(74例)和无效组(26例),选取50例健康志愿者作为对照组。对各组研究对象的血清lncRNA HOTAIR水平、β_2-MG水平进行检测和比较;对病例组患者进行随访,对患者的总生存期(OS)和无疾病进展生存期(PFS)进行观察和比较。结果病例组患者的血清lncRNA HOTAIR水平和β_2-MG水平均显著高于对照组,无效组的血清lncRNA HOTAIR水平和β_2-MG水平均显著高于有效组,差异均有统计学意义(t=18.445、45.023、16.212、22.679,P<0.05);病例组患者及有效组、无效组患者的血清lncRNA HOTAIR水平均与β_2-MG水平具有相关性(r=0.880、0.695、0.893,P<0.05);血清lncRNA HOTAIR水平和β_2-MG水平较高患者的OS、PFS均显著低于血清lncRNA HOTAIR和β_2-MG水平较低的患者,差异均有统计学意义(χ~2=39.435、37.371、38.054、34.696,P<0.05)。结论 MM患者表现为血清lncRNA HOTAIR水平的升高,其水平与β_2-MG水平具有密切的相关性,而且这两种血清标志物水平与化疗药物的治疗效果和生存期有关,可作为评价治疗效果和预测预后的辅助指标。

Objective To analyze the correlation between serum long chain non encoding RNA（lncRNA）HOTAIR expression level,serum beta2-microglobulin（β2-MG）and prognosis in patients with multiple myeloma（MM）.Methods 100 cases of MM patients were selected as the case group and divided into the efficient group（74 cases）and the unefficient group（26 cases）according to the therapeutic effects of chemotherapy.50 healthy volunteers were selected as the control group.The serum lncRNA HOTAIR and β2-MG levels of the objects in each group were detected and compared.The patients in the case group were followed up,the overall survival（OS）and the progression free survival（PFS）of the patients were observed and compared.Results The serum lncRNA HOTAIR andβ2-MG levels of the patients in the case group were significantly higher than those in the control group,the serum lncRNA HOTAIR and β2-MG levels of the patients in the unefficient group were significantly higher than those in the efficient group,the differences were statistically significant（t=18.445,45.023,16.212,22.679,P〈0.5）;The serum lncRNA HOTAIR level was correlated with theβ2-MG level of the patients in the case group,the efficient group or the unefficient group（r=0.880,0.695,0.893,P〈0.5）;OS,PFS of the patients with high level of serum lncRNA HOTAIR orβ2-MG level were higher in patients with low level of serum lncRNA HOTAIR or β2-MG level,the differences were statistically significant（χ^2=39.435,37.371,38.054,34.696,P〈0.5）.Conclusion MM patients show elevated level of serum lncRNA HOTAIR and the level has a close correlation withβ2-MG level.Meanwhile,the levels of two serum markers are correlated with the therapeutic effects of chemotherapeutic agents and the survival of the patients,can be used as assistant indexes to evaluate the therapeutic effects and the prognosis.