大脑中动脉狭窄患者发生轻度认知功能障碍的危险因素分析

Analyze risk factors of mild cognitive impairment in patients with middle cerebral artery stenosis

目的研究大脑中动脉狭窄(MCAS)患者发生轻度认知功能障碍(MCI)的危险因素。方法选取2015年10月至2017年3月收治的MCAS患者108例,其中发生MCI 52例,无MCI 56例。记录患者的年龄、性别、吸烟、饮酒、MCAS程度、受教育程度、缺血性心脏病、收缩压、舒张压、血糖、总胆固醇、三酰甘油、脑血管储备(CVR)、侧支循环通路等指标,分析以上指标与MCI的相关性,探讨MCI的危险因素。结果单因素分析显示年龄、收缩压、血糖、CVR、侧支循环是MCAS患者发生MCI的相关危险因素(均P<0.05)。Logistic回归分析显示,患者的CVR及侧支循环是MCAS患者发生MCI的独立危险因素(OR=0.159,P<0.01;OR=0.372,P<0.05)。结论 CVR及侧支循环是MCAS患者合并MCI的独立危险因素。

Objective To study the risk factors of mild cognitive impairment （ MCI ） in patients with middle cerebral artery stenosis （ MCAS ） . Method A total of 108 patients with MCAS were enrolled in our hospital from October 2015 to March 2017, including 52 cases occurred MCI and 56 cases without MCI. The age, sex, smoking, drinking, MCA stenosis, educational level, post-admission medication, ischemic heart disease, systolic blood pressure, diastolic blood pressure, blood glucose, total cholesterol, triglyceride, cerebrovascular reserve （ CVR ） and collateral circulation of the two groups were recorded. Analyze the above indexes and explore the risk factors of MCI. Results Univariate analysis showed that age, systolic blood pressure, blood glucose, CVR and collateral circulation were the risk factors of MCI in patients with MCAS （ all P〈0.05 ） . Logistic regression analysis showed that CVR and collateral circulation of the patients were the independent risk factors of MCI in patients with MCAS （ OR=0.159, P〈0.01 ; OR=0.372, P〈0.05 ） . Conclusion CVR and collateral circulation were risk factors of MCI in patients with MCAS.