母胎界面微环境改变与早产

Microenvironment of maternal-fetal interface and preterm birth

妊娠第37周前分娩的现象被称为早产。目前,全球每年约有1500万早产儿出生,其中100万早产儿在出生后的1个月内死亡。因此,早产作为一个全球性的问题,为社会带来了严重的负担。探索早产发生的机制,寻找有效的预防方法,是目前亟待解决的科学问题。文章围绕影响母胎界面微环境的3个主要因素即胎儿滋养层细胞、子宫蜕膜和母胎界面免疫细胞,详细阐述母胎界面微环境改变在早产发生中的作用机制。

Preterm birth means that a baby is born before 37 weeks of pregnancy.At present,preterm birth occurs in about 15 million infants, and 1 million among them die within 1 month. Therefore,preterm birth,as a global problem,induces heavy burden on the society.So it is urgent to investigate the mechanisms of preterm birth and find appropriate methods to prevent the incidence of preterm birth. Here we explore three aspects of maternal-fetal interface microenvironment：trophoblast, decidua,and immue cells,to explain how microenvironment change of fetal-maternal interface plays a role in preterm birth.