双胎妊娠早产的预防和治疗

Prevention and treatment of preterm birth in twin pregnancy

双胎妊娠的早产发生率明显高于单胎,也是导致双胎妊娠新生儿死亡的主要因素之一。其确切的发病机制尚不明确。早产的预防和治疗有助于改善双胎妊娠的新生儿结局。超声测量宫颈长度和胎儿纤维连接蛋白检测对双胎早产均具有一定的预测价值。阴道用孕酮治疗、宫颈托及宫颈环扎术对于双胎早产具有一定的预防效果,但既往研究结论不一致,目前在临床中的应用仍有较大争议。

The rate of preterm labor in twin pregnancy was significantly higher than that of singleton pregnancy.Preterm labor was one of the leading causes of infant mortality,and the exact mechanism was not clear.Preterm birth prevention and treatment could improve the outcome of the infants.The ultrasonographic measurements of cervix length and fetal fibronectin test have certain predictive value for preterm labor in twin gestation.The treatment with vaginal progesterone,cerclage of cervix,and pessary insertion might have certain effects on the preterm birth control of twins,but the previous studies don＇t have consistent conclusions and there is still a lot of controversy in the clinical application.