首发精神分裂症患者缓解期神经认知功能和社会认知功能的研究

Neurocognitive and social cognitive functions in first-episode schizophrenic patients in remission

目的:探讨首发精神分裂症患者缓解期神经认知功能和社会认知功能的特点。方法:采用霍普金斯词汇学习测验-修订版(HVLT-R)和中国人面孔情绪测验系统(CFET)评估65例首发精神分裂症缓解期患者(缓解组)、45例首发非缓解期患者(非缓解组)和58名正常人(正常对照组)的神经认知功能和社会认知功能。结果:除保持百分比外,缓解组和非缓解组HVLT-R中各项成绩明显低于正常对照组(P均<0.05);但缓解组即刻记忆和延迟记忆成绩明显优于非缓解组(P均<0.05);缓解组和正常对照组CFET成绩差异无统计学意义;且负性情绪(悲、恐、厌、怒)的正确识别数明显高于非缓解组(P均<0.05);结论:首发精神分裂症患者缓解期社会认知功能基本恢复,而神经认知功能恢复不全。

Objective： To explore the characteristic of neurocognitive and social cognitive function in first-episode schizophrenic patients in remission. Method： Used Hopkins verbal learning test-revised（ HVLT-R） and Chinese facial emotion test（ CFET）,the neurocognitive and social cognitive functions of 65 first-episode schizophrenic patients in remission（ remission group）,45 first-episode schizophrenic patients in non-remission（ non-remission group） and 58 normal controls（ NC group） were assessed and compared. Results：Except the ＂ retention percentage＂,the test results of HVLT-R in remission group and non-remission group were significantly worse than NC group; but the immediate and delayed memory scores of HVLT-R in remission group were obviously better than non-remission group（ all P〈0. 05）. The test results of CFET between the remission group and NC group were not markablely different; and the number of correct identification of negative emotions（ sad,fear,disgust,angry） were significantly higher than the non-remission group（ all P〈0. 05）.Conclusion： Social cognitive function gets recovery basically,but neurocognitive function gets incomplete recovery in first-episode schizophrenic patients in remission.