多发性骨髓瘤肾损害的诊疗进展

Progress in diagnosis and treatment of multiple myeloma patients with renal impairment

多发性骨髓瘤(MM)是指骨髓中浆细胞异常增生所引起的恶性增殖性疾病,其以产生单克隆免疫球蛋白或其片段为特征,进而导致相关器官或组织损害。肾损害是多发性骨髓瘤的常见并发症,且是其主要的致死原因之一。骨髓瘤肾损害发生机制多样,管型肾病和高钙血症是最主要原因。及时有效的诊断并采取适当治疗可改善这类患者总体预后。本文重点阐述骨髓瘤相关性肾损害的诊疗进展。

Multiple myeloma（ MM） refers to a malignant proliferative disorder caused by abnormal proliferation of plasma cells in the bone marrow,which is characterized by the production of monoclonal immunoglobulins or their fragments that subsequently lead to damage to the relevant organs or tissues. Renal damage is a common complication of MM,and is one of the main causes of death. There are various mechanisms of renal damage in MM, among which tubular nephropathy and hypercalcaemia are most important. Timely and effective diagnosis and appropriate treatment plans can improve the overall prognosis of such patients. This article focused on the diagnosis and treatment of myeloma-related renal damage.