IgA肾病预后评估方法研究进展

Progress of research on prognosis evaluation methods in IgA nephropathy

IgA肾病(IgAN)为全世界最常见的原发性肾小球肾炎。该病虽然为慢性进展性疾病,但预后的个体差异极大。因此预后的评估和终点事件预测一直是研究的热点问题。目前IgAN预后评估的方法主要包括病理分型(Lee氏分级、牛津分型等)、临床指标(基线蛋白尿、eGFR等)、数学模型(ARR评分、GOTO模型)以及生物标志物(尿液TGF-β1、IL-6等)。多种方法为IgAN预后的早期预测及干预提供了手段,但各有利弊,该文对近年研究进展进行综述。

Ig A nephropathy（ Ig AN） is the most common primary glomerulonephritis in the world.Although it is a chronic progressive disease,the prognosis of individuals varies greatly. Therefore,the prognosis assessment and the end-point event prediction have been hot issues of study. At present,the prognosis-assessing methods of Ig AN mainly include pathological classification（ Lee＇ s classification,Oxford classification,etc）,clinical indicators（ baseline proteinuria,e GFR,etc）,mathematical models（ ARR score,GOTO model）,and biomarkers（ urinary TGF-β1,IL-6,etc）. A variety of methods provides means for the early prediction and intervention of Ig AN prognosis, but each method has its advantages and disadvantages,of which recent research progress was reviewed in this article.