谷氨酰胺联合早期肠内营养支持对胃癌患者行3D腹腔镜胃癌根治术后血清T细胞亚群水平及康复进程的影响

Effects of Glutamine Combined with Early Enteral Nutrition Support on the Postoperative Levels of Serum T Cell Subsets and Rehabilitation Progress of Patients with Gastric Cancer Undergoing 3D Laparoscopic Radical Gastrectomy

目的观察谷氨酰胺联合早期肠内营养支持对胃癌患者行3D腹腔镜胃癌根治术后血清T细胞亚群水平及康复进程的影响。方法选取2015年5月至2017年1月我院收治的72例胃癌患者,随机分为对照组和研究组各36例。两组均行3D腹腔镜胃癌根治术,术后对照组予以早期肠内营养支持,研究组在对照组基础上予以谷氨酰胺,比较两组排便时间、肛门排气时间、住院时间、血清T细胞亚群(CD3﹢、CD4﹢、CD8﹢)变化情况。结果研究组患者的肛门排气时间、排便时间、住院时间均显著少于对照组(P<0.05)。治疗后,研究组的CD8^+水平显著低于对照组,CD3^+、CD4^+水平均显著高于对照组(P<0.05)。结论予以行3D腹腔镜胃癌根治术胃癌患者谷氨酰胺联合早期肠内营养支持,可增强患者机体免疫功能,促进患者康复。

Objective To observe the effects ofglutamine combined with early enteral nutrition support on the postoperative levels of serum T cell subsets and rehabilitation progress of patients with gastric cancer undergoing 3D laparoscopic radical gastrectomy. Methods 72 cases of patients with gastric cancer in our hospital from May 2015 to January 2017 were randomly divided into control group and study group, with 36 cases in each group. All patients were treated with 3D laparoscopic radical gastrectomy. After surgery, the control group received early enteral nutrition support, and the study group received glutamine on the basis of the control group, to compare defecation time, anal exhaust time, hospitalization time, serum T cell subsets （CD3＋, CD4＋, CD8＋） changes between the two groups. Results The anal exhaust time, defecation time and hospitalization time of the study group was significantly shorter than that of the control group （P 〈0.05）. After treatment, CD8＋ level of the study group was significantly lower than that of the control group, and CD3＋ and CD4＋ levels were significantly higher than those of the control group （P 〈0.05）. Conclusions Glutamine combined with early enteral nutrition support applied in patients with gastric cancer undergoing 3D laparoscopic radical gastrectomy can enhance immune function and promote rehabilitation of patients.