单唾液酸四已糖神经节苷脂联合小剂量泼尼松在治疗难治性癫痫中的脑保护作用

The Neuroprotective Effect of Monosialotetrahexosylgangliosides Combined with Low-Dose Prednisone in the Treatment of Intractable Epilepsy

目的研究单唾液酸四已糖神经节苷脂联合小剂量泼尼松在治疗难治性癫痫的脑保护作用。方法选择80例难治性癫痫患者随机均分为观察组与对照组各40例。所有患者均继续服用原抗癫痫药物,观察组在此基础上使用单唾液酸四己糖神经节苷脂静脉滴注和小剂量泼尼松冲击治疗。结果观察组患者的总有效率为92.50%,显著高于对照组的70.00%(P<0.05)。观察组患者的总智商(FIQ)、言语智商(VIQ)、操作智商(PIQ)、记忆商(MQ)评分均显著高于对照组(P<0.05)。结论单唾液酸四已糖神经节苷脂联合小剂量泼尼松治疗难治性癫痫具有良好的临床疗效,能起到明显的脑保护作用。

Objective To study the neuroprotective effect of monosialotetrahexosylgangliosides （GM-I） combined with low-dose prednisone in the treatment of intractable epilepsy. Methods 80 cases of patients with intractable epilepsy were selected and randomly divided into the control group and the observation group equally. All cases received original antiepileptic drugs continuously; in addition, the observation group receiyed GM-1 for intravenous infusion and low-dose prednisone for pulse therapy. Results The total effective rate of observation group was 92.50%, significantly higher than 70.00% of control group （P 〈0.05）. The scores of FIQ, VIQ, PIQ and MQ of observation group were significantly higher than those of control group （P 〈0.05）. Conclusions GM-1 combined with low-dose prednisone has good clinical curative effect in the treatment of intractable epilepsy, which shows obvious neuroprotective effect.