杭州地区羊水染色体检查结果分析

目的探讨羊水染色体核型分析在妊娠中期产前诊断胎儿染色体异常中的应用。方法对杭州市产前诊断中心2015年1月至2016年12月因不同指征行羊水穿刺的4360例妊娠17～26周孕妇进行羊水细胞常规培养及染色体核型分析。结果在培养成功的4345例羊水染色体中，共检出异常核型248例，检出率5．71％。结论孕中期多种产前诊断指征筛查后羊水细胞染色体核型分析是发现染色体异常的重要手段和降低新生儿缺陷的可靠方法。

Objective To discuss the value ofammocentesis and karyotype analysis in prenatal diagnosis of fetal chromosome abnormality. Methods 4360 pregnant woman in Hangzhou Prenatal Diagnosis Center with high risk of fetal chromosome abnormal were performed arnniocentesis and prenatal diagnosis, results of the karyotype were analysed. Results There were 248 chromosome abnormal （ detection rate 5.71% ） in all 4345 cases. Conclusion Amniocentesis and fetal cell chromosome analysis is a reliability test for pregnant woman in second trimester with high risk of chromosomal abnormality.