不同通便药对老年便秘患者出现结肠黑变病的影响

目的探讨长期服用不同种类通便药对老年便秘患者发生结肠黑变病的影响。方法选择行肠镜检查的长期服用通便药物的老年便秘患者，根据其用药情况分为蒽醌组和非蒽醌组，收集两纽患者的基本信息资料，包括年龄、性别、基础疾病、胃肠道手术史、便秘时间和严重程度、用药时间、种类，伴随症状等，比较两组患者结肠黑变病的发生情况。结果两组老年便秘患者的基础情况无明显差异，用药前后的Wexnelr评分基本一致，蒽醌组患者结肠黑变病比例较高，且较为严重。结论不同通便药物治疗便秘的疗效基本一致，但蒽醌类药物可能引起结肠黑变病。

Objective To study the role of different kinds of laxative in melanosis coli occurrence in elder patients with constipation. Methods The elder patients with constipation who used laxative as a long term behavior were recruited. The information of age, sex, basic illness, gastrointestinal operation history, severiW of constipation, history of laxative usage were collected. The patients were divided into two groups according to usage of anthraquinone-containing laxative. The proportions of melanosis coli in these two groups were compared with the help of colonoscope. Results There were no difference of basic condition between two groups. The Wexner score of patients in anthraquinone group was similar to that in non-anthraquinone group before laxative treatment. In addition, the Wexner scores of two groups were at the same level after laxative treatment. However, the proportions of melanosis coli in anthraquinone group was higher than that in non-anthraquinone group, and severer melanosis coli was observed in anthraquinone group. Conclusion Although different laxatives have similar effects on constipation treatment, anthraquinone-containing laxative might cause melanosis cob in elder patients.