腹腔镜辅助胃癌根治术联合新辅助化疗对机体免疫功能及炎性反应的影响

Effect of laparoscope-assisted radical gastrectomy combined with neoadjuvant chemotherapy on immune function and inflammatory response

目的:研究腹腔镜辅助胃癌根治术联合新辅助化疗对机体免疫功能及炎性反应的影响。方法:选择170例胃癌患者,随机分为观察组和对照组各85例;对照组给予腹腔镜辅助胃癌根治术治疗,观察组联合给予新辅助化疗治疗,比较两组的治疗效果。结果:观察组的治疗有效率为89.41%,高于对照组的72.94%(P<0.05);治疗后两组的CD_4^+、CD_3^+以及CD_4^+/CD_8^+均升高(P<0.05),观察组高于对照组(P<0.05);治疗后两组的白介素-6、肿瘤坏死因子-α以及白介素-23水平均降低(P<0.05),观察组低于对照组(P<0.05)。结论:腹腔镜辅助胃癌根治术联合新辅助化疗可以提高对胃癌的治疗效果,提高机体免疫功能,且降低炎性反应。

Objective：To study the effect of laparoscope-assisted radical gastrectomy combined with neoadjuvant chemotherapy on immune function and inflammatory response.Methods：170 patients with gastric cancer in our hospital were randomly divided into two groups,85 cases in each group.The control group was treated with laparoscope-assisted radical gastrectomy,and the observation group was additionally treated with neoadjuvant chemotherapy.The clinical effect of the two groups was compared.Results：The effective rate of the observation group was 89.41 %,which was significantly higher than that of the control group（72.94 %）（P〈0.05）.After treatment,CD_4~＋,CD_3~＋ and CD_4~＋/CD_8~＋ were significantly increased in the two groups（P〈0.05）,and the increase in the observation group was more obvious（P〈0.05）.After treatment,the levels of interleukin-6,tumor necrosis factor-α and interleukin-23 in the two groups were significantly decreased（P〈0.05）,and the decrease levels in the observation group were significantly lower than those in the control group（P〈0.05）.Conclusion：Laparoscope-assisted radical gastrectomy combined with neoadjuvant chemotherapy can improve the clinical effect of gastric cancer,improve the immune function,and reduce the inflammatory response.