帕金森病患者睡眠障碍临床特点及相关因素

Prevalence and correlated factors of sleep disorder in Parkinson's disease patients

目的探讨和分析帕金森病(PD)患者睡眠障碍的临床特征及相关影响因素。方法选取辽宁省金秋医院符合标准的140例PD患者为研究对象,分析PD患者睡眠障碍发生率;并对有睡眠障碍及无障碍的PD患者临床特征进行对比,并且通过PSQI与HAMD、SCOPA-AUT、MMSE评分等进行评估,分析睡眠障碍的影响因素。另外,对PD患者抑郁与睡眠障碍关系进行分析。结果 140例PD患者中,有92例存在睡眠障碍,睡眠障碍发生率为65.7%。有睡眠障碍PD患者的左旋多巴每日用量、病程、PSQI、HAMD评分均明显高于没有睡眠障碍的PD患者(P<0.05)。PD患者不同抑郁状态组的PSQI评分之间存在差异(P<0.05)。结论左旋多巴每日用量、抑郁、病程与PD患者的睡眠障碍相关,抑郁程度越重,表明睡眠障碍越重。

Objective To analyze the clinical features and influencing factors of sleep disorder in Parkinson＇s disease （PD） patients.Methods Totally 140 PD patients were involved in the study. We analyzed the incidence of sleep disorder in the patients and compared the clinical characteristics of PD between the patients with and without the disorder. We adopted Pittsburgh Sleep Quality Index （PSQI）, Hamilton Depression Rating Scale （HAMD）, Scale for Outcomes in Parkinson＇s Disease for Autonomic Symptoms （SCOPA-AUT）, and Mini-Mental State Examination （MMSE） to evaluate the condition of the patients and to explore influencing factors of the sleep disorder in the patients.Results Of the 140 patients, 92 （65.7%） were identified with sleep disorder. The daily dose of dopamine, the course of disease, and the scores of PSQI, HAMD of the patients with sleep disorder were higher than those of the patients without sleep disorder （P 〈 0.05 for all）. There was a significant difference in PSQI score among the patients with various depressive states.Conclusion The daily dose of dopamine, depression, and course of disease are related to sleep disorder and the severity of depression is positively correlated with PSQI score in PD patients.