BDNF Val66Met基因多态性与家庭功能的关联分析

the Association of BDNF Val66Met Gene Polymorphism and Family Function

目的:探讨脑源性营养因子BDNF Val66Met(rs6265)基因多态性与个体感知的家庭亲密度之间的关系。方法:选取BDNF基因rs6265多态性位点,采用聚合酶链式反应和连接酶检测反应(PCR-LDR)检查技术,测定142名青少年罪犯和116名普通中学生的BDNF基因多态性分布,并应用家庭适应性和亲密度量表中文版(FACESIICV)评估家庭功能。结果:等位基因A携带者的家庭实际亲密度和适应性显著低于GG基因型者,其亲密度和适应性的不满意度则显著高于GG基因型者。一般线性模型中,在控制组别、受教育年限及年龄后,rs6265仍与家庭亲密度、亲密度不满度显著相关(P=0.001)。结论:等位基因A携带者所感受到的家庭成员间的情感联系和家庭适应能力较GG基因型者弱,对家庭亲密度和适应性更为不满。

Objective： To study the association of brain-derived neurotrophic factor（BDNF） gcne polymorphism and family cohesion. Methods： The single nucleotide polymorphism（SNPs） of BDNF, rs6265 were analyzed by PCR-LDR geno- typing assay in 258 participants（142 male juvenile offenders and 116 high school students）. The Chinese version of Family Adaptability and Cohesion Evaluation Scales-II（FACESII-CV） was used to evaluate the family function. Results： Family intimacy and adaptability in A carriers were significantly lower than in GG genotype group, and unsatisfaction of intimacy and adaptability were higher in A carriers. In linear models, when controlled the age, education, whether offenders or not, family intimacy and adaptability were still significantly associated with rs6265. Conclusion： The family adaptability and emotional connection with family members are lower in A carriers than in GG groups, and A carriers feel more discontent to family intimacy and adaptability.