药物三联法治疗妊娠期高血压对患者白血病抑制因子表达及围产儿结局的影响分析

Effects of trigeminy medication therapy on the expression of leukemia inhibitory factor and perinatal outcome in patients with gestational hypertension

目的探讨硫酸镁、尼莫地平和拉贝洛尔三联法治疗妊娠期高血压对患者白血病抑制因子(leukaemia inhibitory factor,LIF)表达及围产儿结局的影响。方法将2012年1月2014年5月就诊的200例妊娠期高血压患者,按随机原则分为试验组和对照组,每组100例。试验组给予硫酸镁注射液、尼莫地平片及拉贝洛尔注射液三联法治疗,对照组仅给予硫酸镁注射液治疗,观察2组患者血压水平、白血病抑制因子表达及围产儿结局的差异。结果治疗后2组患者收缩压和舒张压水平均降低,且试验组患者血压水平明显低于对照组,并与正常妊娠组血压水平相近,差异有统计学意义(P<0.05);试验组新生儿评分和新生儿体重明显优于对照组(P<0.05);不良围生儿发生率显著低于对照组,差异有统计学意义(P<0.05);治疗后2组患者LIF水平均升高,且试验组LIP水平升高程度大于对照组,并与正常妊娠组LIF水平相近,差异有统计学意义(P<0.05);2组患者血清LIF水平与新生儿评分、新生儿体重正相关,与不良围产儿结局负相关,差异均有统计学意义(P<0.05)。结论硫酸镁、尼莫地平及拉贝洛尔三联法能够有效调节白血病抑制因子表达水平治疗妊娠期高血压,围产儿结局较好,值得推广与应用。

Objective To investigate the effects of trigeminy medication therapy of magnesium sulfate,nimodipine and labetalol on the expression of leukemia inhibitory factor（ LIF） and perinatal outcome in patients with gestational hypertension. Methods A total of 200 patients with gestational hypertension who were treated in our hospital from January 2012 to May 2014 were randomly divided into experimental group（ n = 100） and control group（ n = 100）. The patients in experimental group were treated by triple therapy of magnesium sulfate injection ＋ nimodipine ＋ labetalol,however,the patients in control group were treated by magnesium sulfate only. The blood pressure levels,the expression levels and perinatal fetus outcome were observed and compared between two groups. Results After treatment,the levels of systolic pressure and diastolic pressure were decreased in both groups,moreover,which in experimental group were significantly lower than those in control group（ P 〈0. 05）. The neonatal scores and neonatal body weight in experimental group were superior to those in control group（ P 〈0. 05）,moreover,the incidence rate of adverse perinatal birth was significantly lower than that in control group（ P 〈0. 05）. After treatment,the levels of LIF were increased in both groups,and the levels of LIF in experimental group were significantly higher than those in control group（ P 〈0. 05）. In addition the serum levels of LIF were positively correlated with neonatal scores and neonatal body weight in both groups,however,which were negatively correlated with the outcome of adverse perinatal birth（ P 〈0. 05）. Conclusion The trigeminy medication therapy of magnesium ＋ nimodipine ＋labetalol can effectively treat gestational hypertension by rugulating the expression levels of LIF,with better perinatal outcome,therefor,which is worth using widely in clinical practice.