呼出气一氧化氮测定在AECOPD患者吸入激素治疗中的价值

The value of exhaled nitric oxide in treatment of inhaled glucocorticoid for AECOPD patients

目的探讨呼出气一氧化氮(Fe NO)检测在评价AECOPD患者吸入激素治疗中的价值。方法选择2016年6月-2017年6月我科住院AECOPD病人96例;根据Fe NO水平与是否吸入激素治疗,分为高Fe NO水平吸入激素组和对照组;低Fe NO水平吸入激素组和对照组。治疗前和治疗一周后分别测定患者Fe NO水平、肺功能(FEV1、FEV1%pred)及CAT评分,比较前后差异。结果高Fe NO水平吸入激素治疗后较治疗前Fe NO值明显降低,差异有统计学意义;高Fe NO水平对照组及低Fe NO水平组治疗前后Fe NO值则无明显降低;不同Fe NO水平,吸入激素治疗组及对照组在治疗前后FEV1与FEV1%pred及CAT评分均有明显改善,差异均有统计学意义;结论通过检测Fe NO值预测慢性阻塞性肺疾病急性加重患者激素治疗反应,避免糖皮质激素过度使用。

Objective To investigate the value of exhaled nitric oxide （FeNO） in the detection of hormone therapy for patients with AECOPD. Methods From 2016. 6 to 2017. 6 ,96 AECOPD patients were selected. According to FeNO level and whetlier inhaled glucocorticoid,they were divided into the inhaled glucocorFeNO level group （the group A）,the high FeNO level group （the group B）,the low FeNO and inhaled glucocorti-coid group （the group C） and the low FeNO group （the group D）. Their FeNOlevvl,pulmonary FEV 1% pred） and CAT scores were compared before and 1 week after treatment among the four groups. ResultsAfter treatment,the level of FeNO was significantly lower than before in the group A,but it showed no significantdifference in the group Band C. For the patients with different FeNOlevels,their FEV1 and FEV 1% pred scores improved significant after the inhalation of glucocorticoid. Conclusion The detectiontients ＇ response to glucocorticoid therapy in AECOPD,so as to avoid the excessive use of glucocorticoid.