无创通气辅助治疗慢性阻塞性肺疾病并发呼吸衰竭的临床效果

Clinical effect of noninvasive ventilation as an adjuvant therapy in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure

目的探讨无创通气(NIV)辅助治疗慢性阻塞性肺疾病(COPD)并发呼吸衰竭的临床效果。方法选取我院2015年5月~2017年5月收治的COPD并发呼吸衰竭患者96例,采用随机数字表法分为观察组(n=48)和对照组(n=48).对照组患者采用传统鼻导管通气辅助治疗,观察组患者采用NIV辅助治疗,比较两组患者治疗前后的心率(HR)、呼吸频率(RR)和动脉血氧饱和度(Pa O2)水平及临床效果。结果治疗前两组患者HR、RR和Pa O2三项指标数据比较,差异无统计学意义(P>0.05);治疗后,观察组患者HR为(23.91±1.49)次/min,RR为(97.20±2.54)次/min,均明显低于对照组的(29.35±2.43)次/min和(116.32±2.61)次/min,差异均有统计学意义(P<0.05),观察组患者Pa O2水平为(83.62±11.23)mm Hg,明显高于对照组的(64.35±9.17)mm Hg,差异有统计学意义(P<0.05);观察组治疗有效率为93.75%,明显高于对照组的75.00%,差异有统计学意义(P<0.05)。结论 NIV辅助治疗COPD并发呼吸衰竭能够有效改善患者病况,促进患者呼吸功能恢复,效果显著,值得推广。

Objective To investigate the clinical effect of noninvasive ventilation （NIV）as an adjuvant therapy in the treatment of chronic obstructive pulmonary disease（COPD） complicated with respiratory failure.Methods From May 2015 to May 2017,96 patients with COPD complicated with respiratory failure in our hospital were enrolled and evenly divided into the observation group （n=48） and the control group （n=48） by the random number table method.In the control group, traditional ventilation via nasal catheter as an adjuvant therapy was used,while in the observation group,NIV was applied.The heart rate （HR）,respiratory rate （RR）,PaO2 level,and clinical effect were compared before and after therapy. Results There was no significant difference in HR,RR,or PaO2 between the two groups before treatment （P〉0.05）.After treatment,in the observation group,the HR and RR were （23.91±1.49） times/min and （97.20±2.54） times/min,which were greatly lower than those in the control group （29.35±2.43） times/min and （116.32±2.61） times/min （P〈0.05）.The PaO2 level in the observation group was （83.62±11.23） mmHg,higher than that in the control group （64.35±9.17） mmHg,the differences were statistically significant （P〈0.05）.The therapeutic effectiveness rate in the observation group was 93.75%,superior to that in the control group accounting for 75.00%,the difference was statistically significant （P〈0.05）. Conclusion NIV as an adjuvant therapy in the treatment of COPD complicated with respiratory failure can effectively improve the patient＇s condition,promote the recovery of respiratory function.The effect is remarkable,and is worthy of promotion.