尿酸、血浆胱抑素C、超敏C反应蛋白在急性脑梗死颈动脉粥样硬化形成中的意义

Significance of uric acid,plasma cystatin C and high sensitive C reactive protein in the formation of carotid atherosclerosis in acute cerebral infarction

目的探讨尿酸、血浆胱抑素C、超敏C反应蛋白在急性脑梗死颈动脉粥样硬化形成中的意义。方法随机抽取2014年1月~2016年12月南昌市第三医院神经内科收治的100例急性脑梗死患者作为观察组,对患者临床资料进行回顾性分析。另选择同期我院健康体检中心排除脑梗死以及颈动脉粥样硬化病变的100例健康志愿者作为对照组。比较两组的尿酸、血浆胱抑素C、超敏C反应蛋白水平。在此基础之上,根据颈动脉粥样硬化斑块程度分为软斑块组、硬斑块组以及混合斑块组,比较其尿酸、血浆胱抑素C、超敏C反应蛋白水平。根据预后效果分为预后良好组以及预后不良组,同样就三项指标检出值差异进行对比分析。结果观察组的血清尿酸水平显著低于正常组,血浆胱抑素C、超敏C反应蛋白水平均显著高于对照组,差异有统计学意义(P<0.05)。软斑块的血清尿酸水平显著低于硬斑块组和混合斑块组,软斑块组的血浆胱抑素C、超敏C反应蛋白水平均显著高于硬斑块组和混合斑块组,差异有统计学意义(P<0.05)。混合斑块组的血清尿酸水平显著低于硬斑块组,血浆胱抑素C水平、超敏C反应蛋白水平均显著高于硬斑块组,差异有统计学意义(P<0.05)。预后不良组的血清尿酸、血浆胱抑素C、超敏C反应蛋白水平与预后良好组比较,差异有统计学意义(P<0.05)。结论尿酸、血浆胱抑素、超敏C反应蛋白与急性脑梗死患者颈动脉粥样硬化形成有密切相关性,三者共同参与急性脑梗死颈动脉粥样硬化的发生与发展过程,必须引起临床重视。

Objective To investigate the significance of uric acid,plasma cystatin C and high sensitivity C reactive protein in the formation of carotid atherosclerosis in acute cerebral infarction.Methods 100 cases of acute cerebral infarction treated in the Neurology Department of the Third Hospital of Nanchang City from January 2014 to December 2016 were randomly selected as the observation group,the clinical data of the patients were analyzed retrospectively.In addition, 100 healthy volunteers without cerebral infarction and carotid atherosclerosis lesions were selected as the control group at the health check-up center of our hospital at the same time.The difference Of uric acid,plasma cystatin C and hyper- sensitive C reactive protein between the two group were compared.On this basis,according to the degree of carotid atherosclerotic plaques,all patients were divided into the soft plaque group,the hard plaque group and the mixed plaque group,the level of uric acid,plasma cystatin C and hypersensitive C reactive detection values were compared.According to the prognosisis,all patients were divided into the good prognosis group and the poor prognosis group,and the same three indexes were compared.Results The level of serum uric acid in the observation group was significantly lower than that in the normal group,the levels of plasma cystatin C and hypersensitive C reactive protein in the observation group were significantly higher than those in the control group,with significant difference （P〈0.05）.The serum uric acid level of the soft plaque group was significantly lower than that of the hard plaque group and the mixed plaque group,the levels of plasma cystatin C and high sensitive C reactive protein in the soft plaque group were significantly higher than those in the hard plaque group and the mixed plaque group,with significant difference （P〈0.05）.The level of serum uric acid in the mixed plaque group was significantly lower than that in the hard plaque group,and the level of plasma cystatin C and hypersensitivity C reactive protein in the mixed plaque group were significantly higher than those in the hard plaque group,with significant difference （P〈0.05）.There was significant difference in the levels of serum uric acid, plasma cystatin C and hypersensitive C reactive protein between the poor prognosis group and the good prognosis group （P〈0.05）.Conclusion Uricacid,plasma cystatin,hypersensitive C reactive protein are closely related to the formation of carotid atherosclerosis in patients with acute cerebral infarction.The three parties participate in the occurrence and development of carotid atherosclerosis in acute cerebral infarction,which must be paid more clinical attention to.