化痰通络法对急性脑梗死痰瘀阻络患者Hcy和hs-CRP的影响

Influence and clinical efficacy of Huatan Tongluo on Hcy and hs-CRP in patients with acute cerebral infarction of phlegm and blood stasis stagnation collaterals syndrome

目的观察化痰通络法对急性脑梗死痰瘀阻络患者Hcy和hs-CRP的影响及临床疗效。方法收集入住医院神经内科的急性脑梗死患者(中医辨证属于痰瘀阻络型)60例,随机分为观察组和对照组,每组30例。对照组采用西医常规的脑梗死二级预防治疗,观察组在对照组治疗基础上加服化痰通络汤剂,在治疗前及治疗14 d后2组进行NIHSS评分,并测定、比较同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)的数值。结果观察组在降低神经功能评分、降低Hcy、hs-CRP方面均优于对照组(P<0.05)。结论对于急性脑梗死痰瘀阻络型患者,化痰通络法可显著改善其神经功能,提高临床疗效,促进患者的功能康复,其作用机制可能与其降低Hcy和hs-CRP水平有关。

Objective To observe the effect and its clinical efficacy of Huatan Tongluo method on Hcy and hs-CRP in patients with phlegm and blood stasis obstruction in acute cerebral infarction. Methods 60 patients with acute cerebral infarction （TCM syndromes belonging to phlegm and blood stasis type） admitted to the hospital neurology department were randomly divided into observation group and control group with 30 cases in each group. The control group was treated with conventional western cerebral infarction secondary preventional treatment. Observation group in the control group based on the treatment plus plus Huatan Tongluo decoction. The NIHSS scores were measured before treatment and after 14 days of treatment, and the val- ues of homocysteine （Hcy） and hypersensitive C-reactive protein （hs-CRP） were compared. Results The observation group had better performance than the control group in reducing neurological function score, reducing Hcy and hs-CRP （P 〈 0. 05 ）. Conclution For acute cerebral infarction phlegm obstruction type patients,huatan Tongluo collaterals method can significantly improve their neurological function and clinical efficacy and promote functional rehabilitation of patients. Its mechanism are probably related to its lower levels of Hcy and hs-CRP.