快步走改善阿尔茨海默病患者睡眠障碍的疗效观察

Efficiency of brisk walking on sleep disorders in Alzheimer's disease patients

目的探讨快步走对阿尔茨海默病(AD)患者睡眠障碍的治疗效果。方法入选2015年12月至2016年12月北京老年医院精神心理二科收治的72例轻、中度AD患者,随机分为对照组(常规治疗)和运动组(常规治疗+快步走),每组各36例,对照组维持原有的生活习惯,采用常规药物进行治疗;运动组在常规治疗的基础上,进行每日≥60 min、≥3次/周的快步走。采用匹兹堡睡眠质量指数量表(PSQI)对睡眠障碍严重程度进行评估,以PSQI减分率评定疗效。采用SPSS 13.0统计软件对数据进行分析,根据数据类型,组间比较采用配对样本t检验、独立样本t检验或χ2检验。结果治疗12周后,运动组PQSI总分及睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能障碍得分较治疗前均明显下降,差异有统计学意义(P<0.05),且与对照组相比亦显著下降,差异有统计学意义(P<0.05);对照组仅PQSI总分较治疗前下降[(15.53±3.33)vs(14.94±3.53)分],差异有统计学意义(P<0.05),余各因子得分变化不明显。运动组总有效率高于对照组[55.6%(20/36)vs 19.4%(7/36);P<0.05]。结论快步走辅助常规治疗可有效改善AD患者的睡眠障碍。

Objective To investigate the effect of brisk walking on sleep disorders in Alzheimer's disease( AD) patients.Methods Totally 72 patients with mild to moderate AD admitted in our hospital from December 2015 to December 2016 were enrolled in this study,and they were randomly divided into control group( conventional therapy) and exercise group( conventional therapy +brisk walking),with 36 patients in each group. The control group maintained their original living habits,and were given conventional medications,while the exercise group were asked for a brisk walk for ≥60 min/d,≥3 times per week,besides conventional therapy.Pittsburgh sleep quality index( PSQI) was used to evaluate the severity and improvement of sleep disorders. SPSS statistics 13. 0 was used to analyze the data. For different data types,paired sample t test,independent sample t test or Chi-square test was employed for the comparison between groups. Results After 12 weeks of treatment,the exercise group had significantly decreased total PSQI score and the scores in sleep quality,time to fall sleep,sleep duration,sleep efficiency,sleep disorders,daytime dysfunction when compared with the scores before treatment( P < 0. 05),and these scores were obviously different with those of the control group( P < 0. 05). For the control group,only the total PSQI score was decreased significantly [( 15. 53 ± 3. 33) vs( 14. 94 ± 3. 53) score;P < 0. 05],but no such differences were seen in the other scores. The total efficiency of the exercise group was higher than that of control group [55. 6%( 20/36) vs 19. 4%( 7/36); P < 0. 05]. Conclusion Conventional therapy with brisk walking can effectively release sleep disorders in the AD patients.