摘要
目的探讨卵圆孔未闭(PFO)对无先兆偏头痛(MwoA)患者脑白质病变(WMLs)的影响。方法对35例临床确诊的MwoA患者进行经颅多普勒超声(cTCD)检查及磁共振成像(MRI)检查,根据患者是否合并PFO进行分组,匹配年龄、性别及头痛特征资料,观察磁共振液体衰减反转恢复序列(Flair)图像并比较分析PFO阳性组及阴性组间WMLs差异。结果 MwoA合并PFO 19例,其中WMLs阳性7例,病灶分布于额叶和(或)顶叶,白质评分1~7分;MwoA不合并PFO 16例,其中WMLs阳性5例,病灶亦分布于额叶和(或)顶叶,白质评分1~3分,组间WMLs差异无统计学意义(P>0.05)。结论 MwoA患者的脑白质病变多发生于额、顶叶,尚未发现PFO与MwoA患者的脑白质病变相关。
Objective To explore the effect of patent foramen ovale(PFO)on white matter lesions(WMLs)in migraine without aura(MwoA).Methods Thirty-five patients with MwoA were examined by contrast transcranial Doppler(cTCD)and magnetic resonance imaging(MRI).According to the results of PFO and MRI Flair data,the patients' age,sex and headache characteristics were matched,and the WMLs were compared between the PFO positive group and negative group.Results Seven cases of WMLs were recruited in PFO positive group(19 cases)and the WMLs were distributed in the frontal lobe and/or the parietal lobe.The score ranged from1 to7 points.Five cases of WMLs were enrolled in PFO negative group(16 cases)and the WMLs also were distributed in the frontal lobe and/or the parietal lobe.The score ranged from1 to3 points.There was no significant difference in WMLs between the groups(P>0.05).Conclusion White matter lesions in migraine without aura are distributed in the frontal lobe and the parietal lobe,and these findings do not support a relationship between PFO and WMLs.
出处
《西安交通大学学报(医学版)》
CAS
CSCD
北大核心
2018年第2期185-189,209,共6页
Journal of Xi’an Jiaotong University(Medical Sciences)
基金
国家十二五科技支撑计划资助(No.2014BAI04B05)
西安交通大学第一附属医院院基金资助(No.2016MS-02)~~
关键词
无先兆偏头痛
卵圆孔未闭
脑白质病变
磁共振成像
migraine without aura
patent foramen ovale
white matter lesion
magnetic resonance imaging