宫颈上皮内瘤变的进展预警

Prediction of the Progress of Cervical Intraepithelial Neoplasia

宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)是宫颈浸润癌的癌前病变。CIN的发生和进展是一个多因素、多水平的过程。大量研究证实高危型人乳头瘤病毒(human papillomavirus,HPV)持续感染是宫颈癌及CIN的重要致病原因之一,其与宫颈癌的发生、发展有着密切的关系。随着分子生物学的发展和测序技术的进步,阴道微生物与HPV在CIN和宫颈癌的协同作用逐渐被认识。而寻找和探索对CIN进展有判断价值的生物标志物,预警CIN的进展已经成为目前宫颈病变研究的一大热点。综述与CIN进展有关的原因、影响因素及标志物等,以期预警CIN的进展,正确分流及规范管理CIN。

Cervical intraepithelial neoplasia(CIN) is a precursor lesion for cervical cancer. The occurrence and progression of CIN is a multi-factor, multi-level process. Numerous studies have confirmed that high-risk HPV persistent infection is an important tumorigenesis cause of CIN and cervical cancer and is closely associated with the development of cervical cancer. With advances in molecular biology and the development of sequencing technology, the association of low genital tract microbiota with human papillomavirus(HPV) in the development of cervical intraepithelial neoplasia and cervical cancer is gradually being recognized. It has become a popular study to find and explore the prognostic biomarkers of CIN to predict the progression of CIN. This paper reviews the etiology, the influencing factors, and the markers associated with the progression of CIN, in order to properly predict the development of CIN, regulate the diversion and cervical intraepithelial management.