PPAR γ在子宫内膜癌中的研究进展

Research Progress of PPAR γ in Endometrial Cancer

过氧化氢酶增殖物激活受体(peroxisome proliferator-activated receptors,PPARs)是细胞核雌激素受体家族成员,包括PPARα、β/δ和γ。PPARγ参与脂肪与碳水化合物的代谢过程,因与多种代谢性疾病及肿瘤形成密切相关而成为研究的热点。PPARγ是配体依赖的转录因子,与子宫内膜癌细胞的增殖、侵袭和转移有关,但在子宫内膜癌中的研究较少,且具体作用机制尚不明确。综述PPARγ在子宫内膜癌相关的研究进展,旨在探讨PPARγ参与子宫内膜癌发生发展的机制,为临床后续的抗肿瘤治疗提供理论依据。

Peroxisome proliferator-activated receptors(PPARs) are members of nuclear-hormone-receptor family which including PPARα, β/δ and γ. As a hotspot of researches in recent years, PPAR γ is closely related to a variety of metabolic diseases and tumors, which plays an important role in metabolism of lipid and carbohydrate. It functions as ligand-dependent transcription factors, connected with the proliferation,invasion and migration of endometrial cancer cells. The role of PPAR γ in tumorigenesis of endometrial cancer remains unclear. In this article, we reviewed studies progress of PPAR γ in endometrial cancer, discussing the role of PPAR γ in tumorigenesis of endometrial cancer and potential mechanism underlying endometrial cancer development and furthering propose theoretical basis for anti-tumor therapy.