益气活血方对急性颈髓损伤患者血液流变学及凝血功能的影响

Effects of Yiqi Huoxue Fang(益气活血方) on Blood Rheology and Coagulation Function in Patients with Acute Cervical Spinal Injury

目的:观察益气活血方对急性颈髓损伤患者血液流变学及凝血功能的影响。方法:将符合纳入标准的76例急性颈髓损伤患者按照随机数字表法分为两组:对照组(37例)采用西医常规治疗;观察组(39例)在常规治疗基础上联合中药益气活血方治疗,每日1剂,分两次服用,疗程2周。比较两组患者治疗前后血液流变学及凝血功能指标的变化并统计分析两组VTE的发生率。结果:观察组在治疗7、14d后的全血黏度和血浆黏度均低于治疗前(P<0.05),对照组在治疗14 d后低切全血黏度、血浆黏度均低于治疗前(P<0.05);同时期观察组治疗14 d后的全血黏度和血浆黏度均低于对照组(P<0.05)。观察组治疗7、14 d后FIB含量低于治疗前(P<0.05),治疗7 d后D-Dimer及14 d后的FIB、D-Dimer均低于对照组(P<0.05),两组治疗7、14 d后的D-Dimer均明显低于治疗前(P<0.01),两组在治疗前后的HCT比较无统计学意义(P>0.05)。两组治疗14 d后,观察组VTE的发生率明显低于对照组(P<0.05)。结论:益气活血方可改善急性颈髓损伤患者的血液流变学,降低血黏度,减少VTE的发生。

Objective： To investigate the effects of Yiqi Huoxue Fang on coagulation function and blood rheol- ogy in patients with acute cervical spinal injury. Methods：76 patients of acute cervical spinal cord injury were di- vided into two groups according to the random number table , the control group （37 eases） were treated with rou- tine Western medicine;observation group （39 cases） were treated with Chinese medicine Yiqi Huoxue Fang on the basis of conventional treatment, a dose daily, taken two times, treatment for 2 weeks. Comparing the changes of blood rheology and blood coagulation function indexes between the two groups before and after treatment, and sta- tistical analysis the incidence of VTE of the two groups. Results：The whole blood viscosity and plasma viscosity were lowered in treatment group after treatment for 7 days and 14 days ,the differences were significant to compare with before treatment （P 〈 0. 05）, the low whole blood viscosity and plasma viscosity were lowered in the control group after treatment of 14 days （P 〈 0. 05） ;the whole blood viscosity and plasma viscosity were lower in the ob- servation group after treatment 14 days than those in the control group at the same time （P 〈 0. 05 ）. FIB was low- er than before treatment in the observation group after treatment for 7 days and 14 days （P 〈 0. 05）, D - Dimer after 7 days ,FIB and D - Dimer after 14 days in the observation group were lower than those in the control group （ P 〈 O. 05 ）, D - Dimer after treatment 7 days and 14 days in the two groups were significantly lower than before treatment （P 〈 0. 01 ）, HCT changes in the two groups before and after the treatment were no statistical signifi- cance （P 〉 O. 05 ）. After treatment 14 days, the incidence of VTE in observation group was significantly lower than that of the control group （P 〈 0. 05）. Conclusion： Yiqi Huoxue Fang can improve the blood rheology , reduce the blood viscosity and the occurrence of VTE in patients with cervical spinal injury.