纳洛酮联用无创呼吸机治疗老年慢性阻塞性肺疾病合并呼吸衰竭74例疗效研究

The Effect of Naloxone Combined With Noninvasive Ventilator in the Treatment of 74 Cases of Senile COPD With Respiratory Failure

目的探讨纳洛酮联用无创呼吸机治疗老年慢性阻塞性肺疾病合并呼吸衰竭的临床效果。方法选取2013年1月—2017年1月收治的148例老年慢性阻塞性肺疾病合并呼吸衰竭患者随机分为观察组、对照组,两组患者均接受无创呼吸机治疗,观察组在此基础上,使用纳洛酮治疗,观察两组临床效果,并对比血气分析及生命体征指标。结果观察组总有效率为93.24%,高于对照组的81.08%,差异具有统计学意义(P<0.05);两组动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、pH等血气分析指标对比,差异具有统计学意义(P<0.05);观察组呼吸(RR)、心率(HR)、血氧饱和度(SaO_2)等指标均优于对照组,差异具有统计学意义(P<0.05)。结论对老年慢性阻塞性肺疾病合并呼吸衰竭患者实施纳洛酮联用无创呼吸机治疗效果更佳。

Objective To investigate the clinical effect of naloxone combined with noninvasive ventilator on senile COPD patients with respiratory failure. Methods From January 2013 to January 2017, 148 cases of elderly COPD patients with respiratory failure were randomly divided into observation group and control group, all received noninvasive ventilator treatment. On the basis of this observation, the observation group was treated with naloxone. The clinical effects of the two groups were observed, and blood gas analysis and vital signs were compared. Results The total efective rate of the observation group was 93.24%, which was higher than that of the control group （81.08%）, and the difference was statistically significant （P 〈 0.05）. Two groups of arterial oxygen partial pressure （PaO2）, arterial carbon dioxide partial pressure （PaCO2）, pH and other blood gas analysis indicators were compared, the difference was statistically signifcant （P 〈 0.05）. The respiratory （RR）, heart rate （HR） and blood oxygen saturation （SaO2） in the observation group were better than those in the control group, and the diference was statistically signifcant （P 〈 0.05）. Conclusion The efect of naloxone in combination with noninvasive ventilator in elderly COPD patients with respiratory failure is better.