帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍临床效果分析

Analysis of Clinical Effect of Paroxetine Combined With Olanzapine in the Treatment of Depression and Sleep Disorder

目的使用帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍的临床效果分析。方法随机将入住我院的经患者同意的抑郁症合并睡眠障碍的60例患者平分为研究组、对照1组、对照2组,每组各20例,三组患者分别服用帕罗西汀与奥氮平、帕罗西汀、奥氮平药物治疗。分别观察记录分析三组的不良反应、缓解效率(HAMD评分计算)与睡眠时间等指标,观察治疗效果。结果对比分析结果得出,与对照组1组、对照组2组相比,研究组的不良反应少,睡眠时间长,缓解效率高,差异均具有统计学意义(P<0.05)。结论帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍的疗效较单一服药效果好,改善了患者睡眠质量,有利于患者恢复。

Objective To analyze the clinical efect of paroxetine combined with olanzapine in the treatment of depression complicated with sleep disorder. Methods 60 cases of patients with depression and sleep disorders admitted to our hospital were randomly divided into the study group, the 1 control group and the 2 control group, 20 cases in each group. The three groups were treated with paroxetine combined with olanzapine, paroxetine and olanzapine respectively. Observation on and analysis of the three groups of adverse reactions, relief efciency （HAMD score calculation） and sleep time and other indicators, to observe the efect of treatment. Results The results of comparative analysis showed that compared with the 1 control group and the 2 control group, the study group had fewer adverse reactions, longer sleeping time and higher remission efficiency, the difference was statistically significant （P 〈 0.05）. Conclusion The efficacy of the combination of paroxetine and olanzapine in the treatment of depression complicated with sleep disorder is better than that of single administration, which improves the sleep quality of the patients and is beneficial to the recovery of patients .