系统性红斑狼疮并发胃肠道症状的临床研究

Clinical Study of Systemic Lupus Erythematosus Complicated With Gastrointestinal Symptoms

目的分析系统性红斑狼疮(SLE)并发胃肠道症状的临床特征。方法对我院收治的86例SLE患者的临床资料进行分析,根据有无并发胃肠道症状进行分组,分析SLE并发胃肠道症状的有关因素。结果本组SLE并发胃肠道症状的患者共24例,临床表现主要为腹痛、恶心、呕吐、腹泻、消化道出血等;采用Logistic回归模型进行多因素分析,低C3(OR=0.975)、低CH50(OR=0.824)、ANCA阳性(OR=6.430)、雷诺氏现象(OR=3.692)与SLE并发胃肠道症状密切相关(P<0.05),可作为该疾病的独立预测因素。结论胃肠道症状是SLE患者可逆的并发症,ANCA阳性、低补体血症、雷诺氏现象作为SLE并发胃肠道症状的预测因素。

Objective To analyze the clinical features of systemic lupus erythematosus （SLE） complicated with gastric and intestinal symptoms. Methods The clinical data of 86 patients with SLE in our hospital were analyzed, and the related factors of SLE complicated with gastrointestinal symptoms were analyzed according to whether they had concurrent gastrointestinal symptoms. Results In this group, there were 24 cases of SLE with gastric and intestinal symptoms. The main clinical manifestations were abdominal pain, nausea, vomiting, diarrhea, gastrointestinal bleeding and so on. Multivariate analysis was performed using Logistic regressionmodel, low C3 （OR=0.975）, low CH50 （OR=0.824） and ANCA positive （OR=6.430）, Raynaud＇s phenomenon （OR=3.692） associated with SLE complicated with gastrointestinal symptoms （P 〈 0.05）, can be used as independent predictors of the disease. Conclusion Gastrointestinal symptoms are reversible patients with complications of SLE, ANCA positive, hypocomplementemia, Raynaud＇s phenomenon as a predictor of SLE complicated with gastrointestinal symptoms.