清肠合剂灌肠对粘连性肠梗阻血浆胃动素及白细胞介素6的影响

Effect of Qingchang Mixture Enema on Plasma Motilin and IL-6 in Adhesive Intestinal Obstruction

目的:观察清肠合剂灌肠对粘连性肠梗阻血浆胃动素及白细胞介素6(IL-6)的影响。方法:选取粘连性肠梗阻患者60例,随机分为治疗组32例和对照组28例,两组均予常规对症治疗,治疗组配合清肠合剂灌肠,对照组应用肥皂水灌肠。比较两组临床指标及胃动素和IL-6水平变化。结果:治疗组肠鸣音恢复时间(12.5±4.1)h、首次排气时间(40.1±10.2)h、首次排便时间(70.8±17.9)h比对照组肠鸣音恢复时间(20.8±4.7)h、首次排气时间(59.5±12.8)h、首次排便时间(94.0±14.2)h均明显缩短,肠功能恢复快(P<0.01)。治疗组第5 d胃动素(279.0±27.8)pg/m L比治疗前胃动素(210.7±25.0)pg/m L升高,第5 d IL-6(6.7±2.4)pg/m L比治疗前IL-6(12.7±9.7)pg/m L降低(P<0.05)。对照组第5 d胃动素(259.8±25.2)pg/m L比治疗前胃动素(212.3±21.0)pg/m L升高,第5 d IL-6(8.3±3.2)pg/m L比治疗前IL-6(12.0±9.0)pg/m L降低(P<0.05)。治疗组第5 d胃动素高于对照组,IL-6低于对照组(P<0.05)。治疗组治愈率(68.8%)优于对照组治愈率(35.7%)(P<0.05)。结论:清肠合剂灌肠治疗粘连性肠梗阻,能够提高血浆胃动素水平,降低血浆IL-6水平,促进胃肠功能恢复。

：Objective To observe the effect of Qingchang mixture enema on plasma motilin and IL-6 in adhesive intestinal obstruction. Methods Sixty cases of adhesive intestinal obstruction were randomly divided into treatment group （32 cases） and control group （28 cases）. The patients in two groups were given conventional symptomatic treatment. The patients in treatment group were treated with Qingchang mixture enema, and the patients in the control group were given soapy water enema. The clinical parameters, motilin and IL-6 levels in plasma were compared between the two groups. Results The recovery time of bowel sounds [（12.5±4.1） h], time of the ？rst de？ation [（40.1±10.2） h], time of the ？rst defecation [（70.8±17.9） h] in treatment group were significantly shorter than the recovery time of bowel sounds [（20.8±4.7） h], time of the first deflation [（59.5±12.8） h] and time of the ？rst defecation [（94.0±14.2） h] in control group （P 〈 0.01）. In the treatment group, motilin on day 5 [（279.0±27.8） pg/mL] was higher than that before treatment [（210.7±25.0） pg/mL], and IL-6 [（6.7±2.4） pg/mL] was lower than that before treatment [（12.7±9.7） pg/mL] （P 〈 0.05）. Motilinonon day 5 in control group [（259.8±25.2） pg/mL] was higher than that before treatment [（212.3±21.0） pg/mL], and IL-6 on day 5 [（8.3±3.2） pg/mL] was lower than that before treatment [（12.0±9.0） pg/mL] （P 〈0.05）. Motilin in the treatment group was higher than that in the control group on day 5, and IL-6 was lower than the control group （P 〈0.05）. The cure rate of the treatment group （68.8%） was better than that of the control group （35.7%） （P 〈 0.05）. Conclusion Qingchang mixture enema in the treatment of adhesive intestinal obstructioncould increase plasma motilin levels, lower the level of IL-6 and promote the recovery of gastrointestinal function.