蛇毒血凝酶对急性创伤的止血疗效及安全性

Hemostatic Effect and Safety of Reptilase in Patients with Acute Trauma

目的:观察蛇毒血凝酶注射液对急性创伤的止血作用及其安全性。方法:选取急性创伤患者120例,随机分为两组,观察组使用蛇毒血凝酶注射液治疗,对照组使用生理盐水。观察两组止血时间、出血量、单位面积出血量、机体凝血功能指标及肝肾功能变化。结果:观察组止血时间(69.63±23.21)s比对照组缩短,出血量(5.15±1.77)g和单位面积出血量(0.15±0.06)g/cm^2比对照组均减少(P<0.05)。观察组术后30 min、1 d的出血时间、凝血时间较对照组缩短(P<0.05)。两组机体凝血功能、肝肾功能无明显改变,无其他不良反应发生。结论:蛇毒血凝酶注射液对急性创伤具有良好的止血作用,安全性高。

Objective To analyze hemostatic effect and safety of reptilase in patients with acute trauma. Methods Total 120 patients with acute trauma were divided randomly into study group（n=60）and control group（n=60）. Reptilase was used in study group, and normal saline was used in control group. The hemostatic time, hemorrhagic volume, hemorrhagic volume per square unit, coagulation and hepatorenal parameters in two groups were observed and compared. Results The hemostatic time（69.63±23.21）, hemorrhagic volume（5.15±1.77）and hemorrhagic volume per square unit（0.15±0.06）in study group, were signi？cantly different with those in control group（P 〈0.05）. The hemorrhagic and hemagglutinin time in study group were less than those in control group in 30 minutes and 1day after operation, the differences were statistically signi？cant（P 〈0.05）.There were no noticeable change of coagulation and hepatorenal parameters in two groups and no other adverse reactions were observed. Conclusion Reptilase has excellent hemostatic effect and safety in patients with acute trauma.