血虚风燥型特应性皮炎患者皮损干燥与瘙痒的相关性研究

Correlation Between Xerosis and Pruritus Among Patients with Atopic Dermatitis of Blood Deficiency and Wind-dry Pattern

目的探索血虚风燥型特应性皮炎患者皮损干燥与瘙痒的相关性。方法收集血虚风燥型特应性皮炎病例,记录患者皮损的干燥程度,用视觉模拟评分法(VAS)记录患者的瘙痒程度,用修正SCORAD评分(把SCORAD评分中与瘙痒有关的条目去除)评估患者的病情严重程度。用Spearman相关性分析分别研究皮损干燥程度、病情严重程度与瘙痒的相关性。结果血虚风燥型特应性皮炎患者的瘙痒程度与皮损干燥程度、病情严重程度均相关,其相关性均具有统计学意义。结论血虚风燥型特应性皮炎患者的瘙痒程度与皮肤干燥正相关,因此,在治疗时应常规使用保湿剂,以缓解皮肤干燥,减轻患者瘙痒。

Objective In order to explore the correlation of xerosis and pruritus among patients with atopic dermatitis （AD） ofblood deficiency and wind-dry pattern. Methods Patients with AD of blood deficiency and wind-dry pattern were recruitedfrom our hospital. Xerosis was evaluated by one investigator; the severity of disease was evaluated by another investigator usingmodified scoring atopic dermatitis （SCORAD） index. The modified SCORAD index was calculated by removing the symptomspotentially associated with pruritus （ intensity of itching and insomnia） from the standard SCORAD index. Pruritus wasevaluated by patients themselves using visual analogue scale （VAS）. Spearman rank correlation analysis was employed to evaluatethe relationship of pruritus with xerosis and modified SCORAD index, respectively. Results Pruritus of AD correlated withboth xerosis and modified SCORAD index. Conclusion It was suggested that pruritus of AD was correlated with xerosis andemollient or moisturizer should be used to relieve symptoms of xerosis and pruritus when treating AD patients of blooddeficiency and wind-dry pattern.