慢性活动性EB病毒感染治疗进展

Progress in the Treatment of Chronic Active Epstein-Barr Virus Infection

慢性活动性EB病毒感染(chronic active Epstein-barr virus infection,CAEBV)是一种几乎涉及全身各个器官损伤的、EBV感染后T、NK、B细胞异常增生的综合征,主要表现为EBV感染后出现的慢性及反复传染性单核细胞增多症样症状,治疗困难,预后较差。目前国内外通过异基因造血干细胞移植、输注EBV特异性细胞毒性T淋巴细胞等治疗取得了一定进展,现对CAEBV的治疗进展进行综述,以期提高该病的治疗水平。

Chronic Active Epstein-Barr Virus Infection（CAEBV） is a syndrome that involves in the damage of almost all organs of the body and abnormal proliferation of T, NK, B lymphocytes cells following EBV infection, the main clinical symptoms manifested as chronic and recurrent infectious mononucleosis symptoms. The treatment is difficult, the prognosis is poor. At present, some progress has been made in the treatment of allogeneic stem cell transplantation, EBV-specifc cytotoxic T lymphocytes and other related theraoies. Now, the progress of the treatment of CAEBV is summaried in order to improve the therapeutic level of the disease.