Box-Behnken响应面设计法优化排脓散水提工艺

Optimization of Water Extraction Process for Painong Powder by Box-Behnken Response Surface Methodology

目的优选排脓散最佳水提工艺。方法采用Box-Behnken响应面设计法,以水提液中3个指标性成分(柚皮苷、新橙皮苷、芍药苷)的含量和出膏率的综合评价作为考察指标,考察料液比、浸泡时间、提取时间3个因素对提取工艺的影响。结果排脓散水提的最佳工艺条件为15倍水,浸泡67min,提取74min。结论 Box-Behnken实验设计法优化排脓散的水提工艺方法可行,预测性较好。

Objective To investigate the optimal water extraction process for Painong Powder.Methods With the content of three components(naringin,neohesperidin,and paeoniflorin)in water extract and extract yield as the indices of evaluation,Box-Behnken response surface methodology was used to evaluate the effect of solid-liquid ratio,soak time,and extraction time on extraction process.Results The optimal process conditions for water extraction of Painong Powder were 15 times of water,a soak time of 67 minutes,and an extraction time of 74 minutes.Conclusion The water extraction process for Painong Powder optimized by Box-Behnken experimental design is feasible and has good predictability.