老年轻度认知障碍患者抑郁情绪对工具性日常生活能力的影响

Contribution of depression to instrumental ability of daily living among the elderly with mild cognitive impairment

目的探讨老年轻度认知障碍(MCI)患者的抑郁情绪对其工具性日常生活能力的影响。方法采用蒙特利尔认知评估量表进行筛查,其中154例符合MCI诊断者采用老年抑郁量表和功能活动问卷进行抑郁情绪及工具性日常生活能力评估,采用Logistic回归分析老年MCI患者抑郁情绪对工具性日常生活能力的影响。结果 154例老年MCI患者中,49例存在抑郁症状,患病率为31.82%。抑郁组与非抑郁组的社会支持量表分值、主观记忆量表分值、功能活动问卷分值差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,主观记忆水平(OR=1.36,95%CI:1.15~1.61)和抑郁情绪(OR=6.19,95%CI:2.07~18.55)与功能活动问卷分值均呈正性关联。结论老年MCI患者抑郁的患病率较高,抑郁情绪对老年MCI患者的工具性日常生活能力具有独立影响。

Objective To examine the independent effect of depression on activities of daily living of patients with mild cognitive impairment（MCI）. Methods Data were obtained through the face-to-face interview. Totally 154 elderly patients that were screened from 552 old people by the Montreal Cognitive Assessment（Mo CA） were diagnosed as MCI. They were investigated with the Geriatric Depression Scale,and instrumental ability of daily living（IADL） were measured by the Functional Activities Questionnaire. The effect of depression on IADL of patients with MCI was analyzed by logistic regression analysis. Results The prevalence of depressive symptoms among Chinese elders with MCI was 31.82%. The scores of Medical Outcomes Study Social Support Survey, and Functional Activity Questionnaire of depression group and non-depression group were significantly different（P〈0.05）. Logistic regression analysis showed that scores of Functional Activity Questionnaire was positively associated with the scores of Memory Inventory for the Chinese（OR=1.36, 95% CI： 1.15-1.61） and depression（OR=6.19, 95% CI：2.07-18.55）. Conclusion The prevalence of depression in elderly patients with MCI was high. Depression would significantly reduce the IADL of the old patients with MCI. Medical workers should be aware of the extent and impact of depressive symptoms in MCI and take active measures in evaluating and treating the depressive symptoms.