张家口市体检人群高尿酸血症患病现况及影响因素分析

Prevalence and risk factors of hyperuricemia in physical examination group of Zhangjiakou

目的了解河北省张家口市体检人群高尿酸血症患病现况及影响因素,为预防高尿酸血症提供依据。方法以2016年5月—2017年5月在张家口市第一医院进行健康体检者为研究对象,测量身高、体重和血压等体格指标,检测空腹血糖(FPG)、血尿酸(UA)、三酰甘油(TG)和总胆固醇(TC)等血生化指标,采用Logistic回归模型分析高尿酸血症患病的影响因素。结果完成体检17 273人,平均(47.42±14.28)岁,男性10 324人,占59.77%,女性6 949人,占40.23%。检出高尿酸血症3 825例,检出率为22.14%;男性高尿酸血症检出率为28.39%,高于女性的12.87%(P<0.001)。多因素Logistic回归分析结果显示,超重/肥胖(OR=2.206,95%CI:1.986~2.450)、高TG(OR=2.089,95%CI:1.903~2.293)和高TC(OR=1.121,95%CI:1.006~1.249)是男性患高尿酸血症的危险因素;高龄(OR=0.982,95%CI:0.979~0.985)和高FPG(OR=0.657,95%CI:0.587~0.736)是保护因素。高龄(OR=1.008,95%CI:1.001~1.014)、超重/肥胖(OR=2.193,95%CI:1.864~2.579)、高FPG(OR=1.379,95%CI:1.128~1.687)和高TG(OR=2.209,95%CI:1.879~2.597)是女性患高尿酸血症的危险因素。结论张家口市体检人群高尿酸血症患病率较高,超重或肥胖、高TG等是高尿酸血症患病的危险因素。

Objective To investigate the prevalence and risk factors of hyperuricemia in physical examination group of Zhangjiakou,and to provide evidence for the prevention of hyperuricemia. Methods The physical examination people in the Number One Hospital of Zhangjiakou were selected as the research objects from May 2016 to May 2017. Their physique indexes such as height,weight and blood pressure were tested,and their blood sample were collected and biochemical indexes such as fasting plasma glucose（FPG）,blood uric acid（UA）,triglyceride（TG） and total cholesterol（TC） were detected. Logistic regression model were used to analyze the influencing factors of hyperuricemia. Results A total of 17 273 examinees were recruited,with the average age of（47.42±14.28） years. There were 10 324 men（59.77%） and 6 949 women（40.23%）.The prevalence rate of hyperuricemia was 22.14%. The prevalence rate of hyperuricemia in men was 28.39%,higher than that of women（12.87%）（P0.001）. Logistic regression analysis showed that obesity/overweight（OR=2.206, 95% CI： 1.986-2.450）,high TG（OR=2.089,95%CI：1.903-2.293） and high TC（OR=1.121,95%CI：1.006-1.249） were risk factors of the male patients with hyperuricemia,while the elderly（OR=0.982, 95% CI： 0.979-0.985） and high FPG（OR=0.657,95% CI： 0.587-0.736） were protective factors. The risk factors of the female patients with hyperuricemia were the elderly（OR=1.008,95%CI：1.001-1.014）,obesity/overweight（OR=2.193,95%CI：1.864-2.579）,high FPG（OR=1.379,95%CI：1.128-1.687） and high TG（OR=2.209, 95% CI： 1.879-2.597）. Conclusion The prevalence of hyperuricemia among residents in Zhangjiakou of Hebeiis high. Overweight/obesity and high TG are the risk factors for hyperuricemia.