叶酸在4例肾衰伴贫血患儿中的用药指征分析

The medication analysis of folic acid in four cases of children with renal failure and anemia

目的通过叶酸在肾衰伴贫血患儿中的用药指征分析,不仅体现了临床药师在治疗过程中的作用,同时指导了患者合理用药。方法临床药师对4例肾衰伴贫血患儿服用叶酸的治疗过程进行监护,通过检测患儿叶酸水平,对叶酸在此类患儿中的用药指征进行把握。结果肾衰患儿不建议常规补充叶酸,由于过高的叶酸可能使肾衰患儿发生心功能异常,建议结合患儿叶酸水平及亚甲基四氢叶酸还原酶(MTHFR)代谢性,针对性服用叶酸降低肾衰患儿高同型半胱氨酸血症(HHcy)。结论临床药师在临床治疗的过程中,对叶酸在肾衰伴贫血患儿中的使用指征进行分析,指导了患者合理用药。

Objective To analyze the use of folic acid in the children with renal failure and anemia,which indicated the role of the clinical pharmacist in the therapeutic process and provided the reasonable medication guidelines.Methods 4 children with renal failure and anemia treated with folic acid were monitoring,and the medication of folic acid administration in children was controlled by determining the level of folic acid.Results Children with renal failure didn＇t recommend giving routine folic acid supplement,which due to the highly abnormal cardiac function caused by folic acid.It was recommended that we should take into account the folate levels and methylene tetrahydrofolate reductase（MTHFR） metabolism to administrate folic acid pertinently in order to lower the high hyperhomocysteinemia（HHcy） level in the children with renal failure.Conclusion Clinical pharmacists were involved in the adjustment of treatment program,meanwhile,the use of folic acid in children with renal failure and anemia was analyzed to reduce the occurance of short and long-term adverse reactions indicating the their professional value.