线粒体嵴重构及其调控

The Role and Regulation of Mitochondrial Cristae Remodeling

线粒体是生物体内能量产生的主要场所,具有双层膜结构。线粒体内膜向基质延伸折叠形成嵴,在嵴上规律地排列着呼吸链超复合物等多种蛋白,调控氧化磷酸化和电子传递等重要生命代谢活动,为生物体的生长发育提供能量基础。但嵴的形成、形态调控机制、以及嵴动态调控与其生物学功能的内在联系及分子机理都不是很清楚。本文主要介绍线粒体嵴的结构、形成和重构机制、及相关生理病理功能,以促进对线粒体嵴的认识及探索。

Mitochondrion is a double-membrane-bounded organelle; it is the main site of energy production. Mitochondrial cristae are subcompartments of mitochondrial inner membrane,they are arranged orderly and contain the respiratory chain complexes and other proteins which regulate mitochondrial oxidative phosphorylation and electon transfer in mitochondria.Mitochondrial cristae play a serious of biological functions in cells. However,the role and mechanisms of cristae formation and cristae remodeling are poorly known. This review will focus on the structure and remodeling of mitochondrial cristae,introducing the important functions of mitochondrial cristae and its relationship with human diseases,and giving an overlook of understanding in mitochondrial cristae remodeling.