参芪注射液辅助治疗对顽固性心力衰竭患者心功能、心肌纤维化的影响

Effect of adjuvant Shenqi injection therapy on cardiac function and myocardial fibrosis in patients with refractory heart failure

目的:探讨参芪注射液辅助治疗对顽固性心力衰竭患者心功能、心肌纤维化的影响。方法:选择2014年12月~2016年8月在湖北医药学院附属人民医院接受治疗的顽固性心力衰竭患者91例,回顾治疗方案并将其分为接受常规西医治疗的对照组50例、接受参芪注射液辅助常规西医治疗的观察组41例。对比两组患者治疗前后血清中心功能相关指标、心肌纤维化相关指标含量的差异。结果:治疗前,两组患者血清中心功能相关指标、心肌纤维化相关指标含量的差异无统计学意义(P>0.05)。治疗1、3个月后,观察组患者血清中心功能相关指标N末端脑利钠肽前体(NT-proBNP)、和肽素(Copeptin)、生长分化因子15(GDF-15)、骨桥蛋白(OPN)含量较对照组低(P<0.05);血清中心肌纤维化相关指标转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)、Ⅰ型前胶原羧基端肽(PⅠCP)、Ⅰ型原羟基端交联肽(CⅠTP)、Ⅲ型前胶原氨基端肽(PⅢNP)含量较对照组低,脂联素(APN)含量较对照组高(P<0.05)。结论:顽固性心力衰竭患者在常规西医治疗基础上加入参芪注射液辅助治疗,可有效优化患者心功能并抑制心肌纤维化进程。

Objective:To explore the effect of adjuvant Shenqi injection therapy on cardiac function and myocardial fibrosis in patients with refractory heart failure.Methods:Patients with refractory heart failure who were treated in People's Hospital Affiliated to Hubei University of Medicine between December 2014 and August 2016 were reviewed and divided into the control group(n=50)who received routine western medicine treatment and the observation group(n=41)who received Shenqi injection-assisted routine western medicine treatment.The differences in serum levels of cardiac function-related indexes and myocardial fibrosis-related indexes were compared between two groups of patients before and after treatment.Results:Before treatment,the differences in serum levels of cardiac function-related indexes and myocardial fibrosis-related indexes were not statistically significant between the two groups of patients.After 1 month and 3 months of treatment,serum cardiac function-related indexes NT-proBNP,Copeptin,GDF-15 and OPN levels of observation group were lower than those of control group;serum myocardial fibrosis-related indexes TGF-β1,CTGF,PⅠCP,CⅠTP and PⅢNP levels were lower than those of control group whereas APN levels were higher than that of control group.Conclusion:Routine western medicine treatment combined with adjuvant Shenqi injection therapy can effectively optimize the cardiac function and inhibit the myocardial fibrosis process in patients with refractory heart failure.