前列腺素E1联合血必净对脓毒症患者炎症反应进程及靶器官功能的影响

Effect of prostaglandin E1 combined with Xuebijing on the inflammatory response process and target organ function in patients with sepsis

目的:探讨前列腺素E1联合血必净对脓毒症患者炎症反应进程及靶器官功能的影响。方法:选择2014年2月~2017年7月本院接受治疗的脓毒症患者78例,经随机数表法分为对照组、研究组,各39例。对照组患者在常规治疗基础上加入血必净治疗,研究组患者在常规治疗基础上加入前列腺素E1联合血必净治疗。对比两组患者治疗前(T0)、治疗1周后(T1)、治疗2周后(T2)血清中炎症介质及靶器官功能指标含量的差异。结果:T0时,两组患者血清中炎症介质、心肌酶谱指标、肝肾功能指标含量的差异无统计学意义(P>0.05)。T1、T2时,研究组患者血清中炎症介质白介素(IL)-6、IL-10、降钙素原(PCT)、C反应蛋白(CRP)含量低于对照组患者;血清中心肌酶谱指标肌酸激酶同工酶(CK-MB)、高敏心肌肌钙蛋白(hs-cTnT)、乳酸脱氢酶(LDH)含量低于对照组患者;血清中肝肾功能指标尿素氮(BUN)、血肌酐(Cr)、总胆红素(TBIL)、总胆汁酸(TBA)含量低于对照组患者。差异均有统计学意义(P<0.05)。结论:脓毒症患者接受前列腺素E1联合血必净治疗,可有效减轻患者的全身炎症反应并积极保护肝肾功能。

Objective:To explore the effect of prostaglandin E1 combined with Xuebijing on the inflammatory response process and target organ function in patients with sepsis.Methods:78 patients with sepsis patients who were treated in our hospital between February 2014 and July 2017 were divided into control group(n=39)and study group(n=39)by random number table method.Control group received Xuebijing therapy on the basis of routine treatment,and study group received prostaglandin E1 combined with Xuebijing therapy on the basis of routine treatment.The differences in serum levels of inflammatory mediators and target organ function indexes were compared between the two groups before treatment(T0),after 1 week of treatment(T1)and after 2 weeks of treatment(T2).Results:At T0,there was no statistically significant difference in the serum levels of inflammatory mediators,myocardial enzyme spectrum indexes as well as liver and kidney function indexes between the two groups.At T1 and T2,serum inflammatory mediators IL-6,IL-10,PCT and CRP levels of study group were lower than those of control group;serum myocardial enzyme spectrum indexes CK-MB,hs-cTnT and LDH contents were lower than those of control group;serum liver and kidney function indexes BUN,Cr,TBIL and TBA contents were lower than those of control group.Conclusion:prostaglandin E1 combined with Xuebijing can effectively reduce the systemic inflammatory response and actively protect the liver and kidney function of patients with sepsis.