血小板参数在判断强直性脊柱炎疾病活动中的价值

The value of the platelet parameters in evaluating the disease activity of ankylosing spondylitis

目的:探讨血小板计数(PLT)及平均血小板体积(MPV)在判断强直性脊柱炎(AS)病人疾病活动中的作用。方法:比较和分析71例AS病人PLT、MPV与Bath强直性脊柱炎活动性指数(BASDAI)评分、红细胞沉降率(ESR)、C反应蛋白(CRP)、免疫球蛋白(IgG)、血红蛋白(Hb)等指标相关性。结果:AS病情活动组PLT均较AS病情稳定组和对照组升高(P<0.01)。AS病人PLT升高组的ESR、CRP、IgG均较PLT正常组升高(P<0.01),而Hb、MPV均降低(P<0.05和P<0.01)。AS病人PLT与ESR、CRP、IgG均呈正相关关系(P<0.05~P<0.01),与Hb和MPV均呈负相关关系(P<0.01)。结论:PLT和MPV的变化与AS疾病的活动相关,可以作为反映AS病情活动的参考指标之一。

Objective: To explore the value of the platelet count( PLT) and mean platelet volume( MPV) in evaluating the disease activity of ankylosing spondylitis( AS). Methods: The levels of PLT,MPV,scores of Bath ankylosing spondylitis disease activity index( BASDAI),erythrocyte sedimentation rate( ESR),C reactive protein( CRP),immunoglobulin( IgG) and hemoglobin( Hb) in 71 patients with AS were compared and analyzed. Results: Compared with the stable AS patients and control group,the PLT in active AS patients increased( P < 0. 01). Compared with the patients with normal PLT,the levels of ESR,CRP and IgG increased in patients with PLT increasing( P < 0. 01),but the levels of Hb and MPV decreased in patients with PLT increasing( P < 0. 05 and P < 0. 01). The level of PLT in AS patients was positively correlated with the levels of ESR,CRP and IgG( P < 0. 05 to P < 0. 01),and negatively correlated with the levels of Hb and MPV( P < 0. 01). Conclusions: The changes of PLT and MPV are associated with the disease activity of AS,which can be used as one of disease activity indicators in reflecting AS.