平均血小板体积/血小板比值与系统性红斑狼疮活动性的相关性分析

Correlation analysis between mean platelet volume/platelet ratio and systemic lupus erythematosus activity

目的:探讨平均血小板体积/血小板计数比值(MPR)与系统性红斑狼疮(SLE)临床指标的相关性。方法:选取36例SLE病人(SLE组),另选取40名年龄和性别相匹配的同期正常体检人员为对照组(HC组)。对平均血小板体积(MPV)、MPR与SLE病人疾病活动指数(SLEDAI)、红细胞沉降率(ESR)等SLE疾病活动指标行回顾性分析。结果:MPV和MPR在SLE组病人中均高于HC组(P<0.05和P<0.01);ESR与MPV、MPR均呈正相关关系(P<0.01和P<0.05)。SLEDAI与MPR亦呈正相关关系(P<0.01),和MPV未见相关性(P>0.05)。结论:MPR可能是评估SLE疾病活动的良好指标。

Objective: To investigate the correlation between mean platelet volume/platelet ratio( MPR) and systemic lupus erythematosus( SLE). Methods: Thirty-six SLE patients and 40 age-and gender-matched medical examiner were divided into the SLE group and control group,respectively. The MPV,MPR,SLE disease activity index( SLEDAI) and erythrocyte sedimentation rate( ESR)were retrospectively analyzed. Results: The levels of MPV and MPR in SLE group were higher than those in control group( P < 0. 05 and P < 0. 01). The ESR was positively correlated with MPV and MPR( P < 0. 01 and P < 0. 05). The MPR was positively correlated with SLEDAI( P < 0. 01),and the MPV was not obviously correlated with SLEDAI( P > 0. 05). Conclusions: MPR may be an useful index in estimating the SLE activity.