他汀类药物对腹主动脉瘤患者血清炎性因子的调节作用

Statin Therapy Regulates Serum Inflammatory Factors in the Treatment of Abdominal Aortic Aneurysms

目的评估他汀类药物治疗对腹主动脉瘤(AAA)患者血清炎性因子的影响。方法回顾性分析2014年9月至2017年9月在北京协和医院血管外科住院治疗的126例AAA患者的临床资料,根据是否应用他汀类药物将患者分为治疗组与对照组,比较两组患者的血脂和血清炎性因子水平。结果两组患者在性别、年龄、身高、体质量、吸烟比例和AAA直径方面差异均无统计学意义(P均>0.05)。治疗前两组患者的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)水平差异均无统计学意义(P均>0.05);治疗后治疗组患者的TC(t=2.868,P=0.009)、TG(t=3.472,P=0.006)和LDL-C水平(t=3.924,P=0.005)明显低于对照组,HDL-C水平明显高于对照组(t=3.322,P=0.007)。治疗前两组患者的白细胞介素(IL)-1β、IL-6、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)浓度差异均无统计学意义(P均>0.05)。治疗后治疗组患者的血清IL-1β和IL-6浓度分别为(224.32±78.54)和(116.49±19.64)ng/L,与对照组的(254.68±96.77)(t=1.765,P=0.058)和(126.71±23.59)ng/L(t=1.692,P=0.063)差异均无统计学意义;hs-CRP和TNF-α水平分别为(6.46±1.24)mg/L和(0.77±0.21)μg/L,明显低于对照组的(10.93±4.18)mg/L(t=2.007,P=0.012)和(1.28±0.49)μg/L(t=2.144,P=0.016)。结论他汀类药物治疗可降低AAA患者体内的hs-CRP和TNF-α水平。

Objective To assess the effect of statin therapy on serum inflammatory cytokines in patients with abdominal aortic aneurysm(AAA).Methods The clinical data of 126 AAA patients who were hospitalized in the Department of Vascular Surgery,Peking Union Medical College Hospital,from September 2014 to September 2017 were retrospectively analyzed.Patients were divided into treatment group and control group ac-cording to whether statins were used or not.The levels of serum lipids and serum inflammatory factors were compared between these two groups.Results There was no significant difference in gender,age,body height,body weight,smoking ratio,and AAA diameter between these two groups(all P>0.05).While the levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) were not significantly different before treatment(all P>0.05),the treatment group had significantly lower TC(t=2.868,P=0.009),TG(t=3.472,P=0.006),and LDL-C(t=3.924,P=0.005) and significantly higher HDL-C level(t=3.322,P=0.007) after treatment.In addition,the concentrations of interleukin(IL)-1β,IL-6,high-sensitivity C-reactive protein(hs-CRP),and tumor necrosis factor-α(TNF-α) were not significantly different between these two groups before treatment(all P>0.05);after treatment,the serum levels of IL-1β and IL-6 in the treatment group were(224.32±78.54) and(116.49±19.64) ng/L,respectively,which were lower than those in the control group [(254.68±96.77)ng/L(t=1.765,P=0.058) and(126.71±23.59) ng/L(t=1.692,P=0.063) ],although the differences were not statistically significant.The serum levels of hs-CRP and TNF-α in the treatment group were(6.46±1.24) mg/L and(0.77±0.21) μg/L,respectively,which were significantly lower than those in the control group [(10.93±4.18) mg/L(t=2.007,P=0.012) and(1.28±0.49) μg/L(t=2.144,P=0.016) ].Conclusion Statin treatment reduces the levels of hs-CRP and TNF-α in AAA patients.