Wnt信号通路在胚胎着床中的作用

Contribution of Wnt Signaling Pathway to Embryo Implantation

在哺乳动物中,子宫内膜接受态的建立、激活囊胚的植入和子宫基质蜕膜化是胚胎成功着床的必要条件,对妊娠结局起决定作用。Wnt信号通路与生物体中的细胞增殖、分化、凋亡和再生等多种重要功能息息相关。现有研究表明,Wnt信号通路在胚胎着床过程中发挥着不可替代的作用,其异常表达可能导致子宫内膜异位症或子宫内膜癌等多种生殖系统相关疾病的发生,严重影响人类的寿命和生活质量,本文总结了Wnt信号通路在子宫接受态建立、囊胚激活、胚胎着床以及子宫基质蜕膜化过程中的作用及其相关机制。

The establishment of the endometrial receptive state,the implantation of activated blastocysts,and the decidualization of the uterine stroma are essential conditions for successful implantation in mammals and play decisive roles for subsequent pregnancy outcomes.The Wnt signaling pathway is associated with a variety of key functions such as proliferation,differentiation,apoptosis,and regeneration.During the embryo implantation,the Wnt signaling pathway plays an indispensable role.Studies have shown that the abnormal expression of Wnt signaling pathway can lead to endometriosis,endometrial cancer,and other reproductive diseases that seriously affect human health and quality of life.In this article we summarize the roles of Wnt signaling pathway in the establishment of uterine receptivity,blastocyst activation,embryo implantation,and decidualization and its regulatory mechanisms.