摘要
非结核分枝杆菌(NTM)感染多见于免疫功能损伤的患者。马尔尼菲青霉菌(PM)是一种温度双向型真菌,主要流行于东南亚各国及我国南方地区,常见于人类免疫缺陷病毒(HIV)感染者,非HIV感染者合并两者感染罕见。北京协和医院收治了1例非HIV感染播散性NTM病合并PM病中年男性患者,广西人,临床表现为腹痛、全身淋巴结肿大、体质量下降、发热、骨痛,HIV抗体阴性,血培养NTM阳性,肱骨穿刺组织培养PM阳性,给予抗NTM及伊曲康唑治疗,随诊2年,临床表现良好。
Disseminated nontuberculous mycobacterial(NTM) infection occurs mostly in immunocompromised hosts.Penicilliosis marneffei(PM) is a unique dimorphic fungal infection endemic in Southeast Asia.It is one of the commonest opportunistic infections among human immunodeficiency virus(HIV)-positive patients.There are rare reports about NTM associated with PM infection in non-HIV-infected individuals.Peking Union Medical College Hospital diagnosed a 45-year-old male patient who came from Guangxi Province.He complained of abdominal pain,generalized lymphadenopathy,weight loss,fever,and upper limb pain at presentation.He was HIV-negative,blood culture was positive for NTM,and the result of humerus specimen culture was PM.After treatment with anti-NTM drugs and itraconazole,his clinical status was improved.He remained symptom-free during the 2-year follow-up.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2018年第1期131-135,共5页
Acta Academiae Medicinae Sinicae
关键词
非结核分枝杆菌
马尔尼菲青霉菌
人免疫缺陷病毒阴性
non-tuberculous mycobacteria
penicilliosis marneffei
human immunodeficiency virus-negtive